Anabolic steroids, bodybuilding discussion forums. - SteroidologyAlthough steroids and training are a bit outside of the lab's research interests, they appear to be a topic of great general interest. We've put together these few pages to serve that anabolic steroids androgen receptor and hopefully provide some objective information and a anabolic steroids androgen receptor point for your own investigation meaning we probably won't answer steroid questions. All anabolic steroids are chemical derivatives of the male sex hormone, znabolic. Due to testosterone's short biological half-life, pharmacological use requires the steroid be modified to slow metabolism by the liver. Typically, oral steroids are modified anavar and birth control pill by alkylation replacing an H with a CH 3 groupwhile injectable steroids are modified by esterification of the hydroxyl group.
Understanding the Androgen Receptor | IronMag Bodybuilding Blog
There are currently 2 users browsing this thread. Anabolic steroids, bodybuilding discussion forums. Page 2 of 2 First 1 2 Jump to page: Results 26 to 41 of Which muscles have the most androgen receptors?
Some people say you can tell that someone juices if they have "capped" shoulders. I still dont know wtf that even meens. I guess shoulders have high androgen receptors?? I was also reading on another thread though that the body already produces even naturaly enough testosterone to occupy most receptors.
By Jose Antonio PHD Everybody knows that anabolic steroids, or what most researchers call androgens, promote muscular growth and produce a man's characteristic "maleness": Since women have much less circulating androgen, the effects would be much more profound if they used these hormones.
But how do men get so big? Most sport scientists say that the receptor for testosterone the androgen receptor is fully saturated at normal physiological levels, which means that the average guy has enough circulating androgen to bind to all of his receptor sites. Don't let this science jargon scare you.
When testosterone binds to the androgen receptors in skeletal muscle fibers, it's in essence unlocking a door. When this door is unlocked, certain physiological processes can occur. In the case of androgen and androgen receptors, the end result is larger muscles. Now, if enough keys androgen exist for every lock androgen receptor , then giving someone more keys shouldn't unlock any more doors.
Or can we possibly make more doors androgen receptors for this powerful hormone to open? Muscle obviously responds to androgens. Some scientists believe that the differences in muscle mass between the sexes is related to levels of the androgen receptor.
Men have more and should therefore be sensitized to circulating androgen. It has been postulated that the shoulder deltoids, trapezius and pectoral muscles exhibit higher androgen receptor levels in males than in females, which might explain some of the differences in upper-body size between men and women.
A number of researchers believe that if the androgen receptor is saturated at normal physiological amounts, then any excess androgen would only down-regulate decrease the number or affinity of the receptor.
But androgens don't have the same response in all tissues. For example, a down-regulation of androgen receptors in the penis takes place in response to androgen. It makes sense that as circulating androgens rise in a developing animal, the level of androgen receptors in the penis would decrease along with androgen-induced growth.
As the penis reaches adult size, it consequently becomes insensitive to the anabolic effects of androgen. But is this what occurs in muscle tissue? Androgens seem to exert their anabolic effects through multiple mechanisms. One possibility is that if you take exogenous androgen that is, oral or injectable anabolic steroids , you may actually increase the level of androgen receptors present in skeletal muscle.
If you have more receptors, you'd have an enhanced anabolic effect as a result of steroid use. So guess what happens when you give these rats androgens? They up-regulate, or increase the number of androgen receptors. Big deal, you say. This is just a bunch of chemistry gob-bledygook. Well, if you've been paying attention, you'll see how this scenario might explain why taking greater and greater doses of androgens produces larger and more muscular bodybuilders. A plateauing effect of androgens doesn't seem to occur: The more you take, the more receptors you make, the more sensitized your muscles become and the bigger you get.
It becomes a constant anabolic cycle. Although not proven scientifically, this may explain some of the profound effects seen with steroid use among bodybuilders. Androgens can bind to other receptors, too. Think of this process as being like having a key that fits really well in one door, but if you jiggle and wiggle it a little you can open other locks as well. For instance, androgens may actually bind with receptor sites for glucoconicoids, which would then have an anticatabolic effect.
RU the French abortion pill has been shown to block the glucocorticoid receptor and have anticatabolic properties in skeletal muscle. In fact, some scientists believe this blocking of anticatabolic receptors to be the most important way in which steroids affect muscle. If that's true you'd think the use of RU would be prevalent among serious athletes and bodybuilders, but it isn't.
The bottom line is that androgens may act physiologically through many avenues to produce potent anabolic effects. Given their effects on androgen receptors and their ability to block the effects of muscle-wasting hormones via the glucocorticoid receptor, you're dealing with a very powerful hormone. Just look at today's elite bodybuilders and you'll see what I mean. Originally Posted by darkwing Originally Posted by Mrrippedzilla.
I would ignore all this "aas creates more androgen receptors" and receptors get "downregulated" bullshit. Rat studies dont mean a thing. The guy also admits that none of this has been scientifically proven. All interesting theories, all are non-applicable in real life. Last edited by JimiThing; at Originally Posted by JimiThing. Id pay more attention to something like this that proves that in the presence of excess androgens the androgen receptor half life doubles as does the rate of production of new androgen receptors.
People seem to be under the mistaken belief that there are androgen receptors and they are just there forever etc. The fact is they are constantly replaced. Anyway this pretty much disproves any down regulation nonsense as well as supports an increase in both AR receptors as well as their life span in the presence of excess androgen.
So in spite of the lack of scientific evidence the gentleman we both agree that does not properly support his contentions is in fact pretty much correct. Mechanism of androgen-receptor augmentation. Analysis of receptor synthesis and degradation by the density-shift technique.
The ductus deferens smooth muscle tumor cell line DDT1MF-2 contains receptors for, and is stimulated by, androgens. Cells cultured in the absence of androgens maintain a basal level of androgen receptors. Following incubation with various concentrations of the synthetic androgen methyltrienolone R for h, the concentration of these receptors increased from 6.
The steroid-induced increase in androgen receptor levels was specific for androgens and dependent upon protein synthesis. The mechanism of receptor augmentation was examined by utilization of isotopically dense amino acids to determine rates of receptor appearance and degradation in the presence or absence of [3H]R In the absence of androgens, the half-life of the androgen receptor was 3.
In the presence of 1 nM [3H]R, however, the half-life was 6. The rate constant for receptor synthesis ks in the absence or presence of [3H]R was calculated to be 1.
Thus, androgen-induced androgen-receptor augmentation is explained by an increase both in receptor half-life and in rates of receptor synthesis. Last edited by Mrrippedzilla; at Originally Posted by mprtz. Originally Posted by clman Originally Posted by Buzzbait. Under "Bro-Science" I would have to say delts for me. They are the first thing to blow up when blasting Then could be genetics? Hell I don't know.
What about quads and the rest of our leg since they are predisposed to being some of the most active muscles in our body? That's more like it Although I'm not aware of those results being replicated in vivo, so we're assuming it will still be the same. So if we accept that it is possible to increase androgen receptors, and that any sort of "downregulation" is a myth, is it possible to apply this in a selective manner?
So rather than increase androgen receptors in general, can we increase them in select areas like the calves or other lagging bodyparts? I'm pretty sure there are no definitive answers to these questions but am always interested in your views Jimi. Still to this day that's the sign I used to tell me I got an effective workout. If this was the case site injections of androgens would lead to increases in actual muscle in the muscle where the injection was administered.
As anecdotal as it is I think and size increase due to site injections is more from oil volume and inflammation as opposed to actual AR and life being increased so my opinion on that would be no, we cannot selectively increase the numbers and lifespan in a site specific fashion.
The thing is this as well, the activation of the AR is not a merely site specific phenomenon. The effects are systemic in many ways so AR in certain muscle groups is not necessarily the sole or defining reason for muscle hypertrophy or the ease or difficulty of muscle hypertrophy in certain muscle groups.
It also has to do with the type of muscle fibers that make up those muscle groups as we know the response to resistance training or HOW we train, ie: If IGF does in fact induce muscle cell hyerplasia, can one increase the number of ar's in specific muscles by using site injections of igf?
We could chew on that one for a while as well! Well you need to be a little more clear. If you looking for receptor density that is different then what has the most.
Quads on most people have a higher number of receptors than the other muscle gust because of the size difference. It you think of receptors like parking spaces then the quad parking lot is bigger with a higher number of spaces.