Anabolic steroids, bodybuilding discussion forums. - SteroidologyFrom the desk of George Spellwin - Founder EliteFitness. Billy ahabolic over 6 feet tall and weighs around pounds. Billy was born estrogen anabolic healthy, normal man - good looking, good genetics, naturally strong. But now, when he's not working the talk show circuit, Billy has estrogen anabolic exciting career as an exotic dancer.
How to Lower Estrogen: 8 Effective Natural Methods | Anabolic Men
From the desk of George Spellwin - Founder EliteFitness. Billy stands over 6 feet tall and weighs around pounds. Billy was born a healthy, normal man - good looking, good genetics, naturally strong.
But now, when he's not working the talk show circuit, Billy has an exciting career as an exotic dancer. Some guys just love watching poor Billy shake and shimmy his double D's.
How did Billy grow breasts like the guy in Fight Club with the huge knockers? Our friend Billy used anabolic steroids without anti-estrogens. To understand what happened to poor Billy, in this issue of EliteFitness. Also in this week's EFN, we'll look at drugs you can use to annihilate estrogen in a blinding burst of anabolic goodness! Read on, unless of course you actually want a career in the exotic dancing arts like our friend Billy. Before we begin to talk about all the great benefits of anabolic steroids I think it is important to take a moment to talk about side effects and how to prevent them.
The biggest source of steroid related side effects comes from the impact anabolic steroids have on your body's production of estrogen. So, here is a quick biochemical over-view of estrogen. Estrogens regulate the growth, differentiation, and functioning of diverse target tissues, both within and outside of the reproductive system. Most of the actions of estrogens appear to be exerted via the estrogen receptor ER of target cells, an intracellular receptor that is a member of a large super family of proteins that function as ligand-activated transcription factors, regulating the synthesis of specific RNAs and proteins.
This process is almost identical to the action by which anabolic steroids affect protein synthesis. Estrogen is also a steroid hormone, although not used for athletic enhancement. However, estrogen plays a key role in the use of AAS. Certain steroids, at high enough dosages, can convert via the enzyme aromatase into other hormones; in the case of testosterone-based steroids this other hormone is usually estrogen. Steroids with a dihydrotestosterone DHT base are not subject to aromatization; as a metabolite of testosterone its structure is not affected by the aromatase.
Steroids with alkylated structures generally convert into weaker estrogens. Some steroids, such as nandrolone deca-durabolin or trenbolone parabolan, or in most people's cases Finaplex convert into progesterone. High dosages of steroids for prolonged periods also shut down the body's natural production of certain hormones particularly testosterone when steroid therapy is stopped the body attempts to establish homeostasis by adjusting hormonal levels.
The average ratio of testosterone to estrogen in a healthy male is When drugs increase the testosterone in the body, the body will respond by increasing the estrogen in the body.
Additionally, estrogen circulates in the body bound to the protein SHBG sex hormone binding globulin as does the testosterone. SHBG is produced in the liver and use of steroids increases the production of this protein; which has a very high receptor affinity for testosterone.
With more SHBG in the body, more testosterone is bound, becoming inactive as only free testosterone can activate an androgen receptor. SHBG, however, has poorer receptor affinity for estrogen and more active free estrogen circulates in the body, further altering the hormonal balance. These effects of steroids i. Thus, steroid users seek ways to block this estrogen from affecting them. That is all a very nice and formal way of saying that you need to be taking anti-estrogens when you are using steroids.
See, without the anti-estrogens you get all sorts of pleasant side effects, not limited to a nice pair of breasts with oh -so tender nipples and extra body fat! Without anti-estrogens you will end up like poor Billy, shaking his titties in the face of wealthy Japanese businessmen. No, seriously, this chapter will explore how to effectively use anti-estrogens to prevent many of the side effects that accompany anabolic steroid usage.
The Drugs Are Your Friends. Oral clomiphene citrate Clomid is an ovulation stimulant used to treat ovulatory failure in women. Oral tamoxifen citrate Nolvadex belongs to a class of antineoplastics called antiestrogens. It is used to treat breast cancer. Body builders use both of these drugs. Why on earth would they do that? The answer is that both of these drugs are anti-estrogens. The term anti-estrogen is a little inaccurate.
Rather, let us think of the classical anti-estrogen drugs such as nolvadex and clomid as estrogen receptor antagonists ERA. These ERAs are chemicals that are close enough in structure to estrogen to fit into the estrogen receptor site; however these chemicals do not have the same chemical effect as estrogen.
The result is that any estrogen produced by the body or exogenous estrogen cannot find an open receptor site to attach to. The free-floating estrogen then presents far less problems to homeostasis. There is a lot of conflict over using nolvadex, clomid and other ERAs.
The regulation of estrogen-induced cellular effects is a multi-step molecular process. The diversity of estrogen and anti-estrogen effects on cellular functions is also modulated by tissue and gene specificity. This diversity of reaction may be explained by different levels of molecular regulation, including the presence of two distinct estrogen receptor isoforms ER alpha and ER beta , their binding to activator or co-repressor transcriptional proteins, and their affinity to different DNA binding domains of target genes estrogen responsive element or API.
These mechanisms may account for the specific responses to estrogens or anti-estrogens according to tissue, cell or gene level. Therefore, in English, a drug like nolvadex, which targets breast tissues, is going to do a better job of preventing gynocomastia than is clomid. However clomid has the benefit of boosting the levels of follicle stimulating hormone, which helps restore the bodies natural testosterone levels and protects against testicular atrophy.
Many people stop using their ERA drugs when they end the cycle. That is a terrible idea. Clomid, as we have already discussed, helps immensely with your recovery processes.
But remember, there is almost always an estrogen backlash to having been using testosterone drugs for so long. Therefore, many symptoms of high estrogen levels appear after the cycle. I would continue to use both Clomid and Nolvadex for up to 3 weeks after the last of the drugs have left your body. Remember, if on Friday you take mg of a longer acting drug like Sustanon, then don't consider the following few weeks as truly off time.
That is why it is important to know how long the drugs are effective in your body and yet another reason to switch to faster acting drugs in the last few weeks of a cycle. Effective dosages of these two drugs are debated. I would recommend that the two drugs be used together, Nolvadex at 20 mg per day, and clomid at 50 mg per day. If Nolvadex is used by itself, mg are sufficient. Clomid should be used for two weeks after the last steroid injection to help return your body to its natural hormonal state.
Nolvadex and Clomid are mildly expensive, but very available because they are not scheduled drugs and can be imported. There is a second class of drug used to combat estrogen side effects from what is grandly called steroid therapy; there are aromatase inhibitors. As mentioned previously in this chapter, the body can convert testosterone into estrogen using the enzyme aromatase. This second group of drugs, which I will call the inhibitors, prevents this process from occurring at all.
This class of medication is generally only prescribed for severe conditions and is generally more expensive then any of the ERA. Teslac, testolactone , has fallen out of favor for several reasons. First of all, almost one gram daily is needed to achieve sufficient estrogen synthesis inhibition. This makes this a very expensive drug to use. Also, it is currently a scheduled drug because it is a testosterone derivate.
Cytadren aminoglutethimide is a better choice, requiring dosages of between mg per day to suppress estrogen synthesis. Cytadren is used therapeutically to combat Cushing's syndrome because it also interferes with the body's ability to synthesis cortisol. Sounds like fun, huh What a fantastic environment. Tell that to Andreas Munzer! Cytadren can cause cysts as well as effect things like blood clotting. It is reported that Munzer used g! Therefore cytadren use should be done with precision.
Arimidex anastrozole is a drug designed to combat second stage breast cancer. It is an extremely potent drug; one pill per day is sufficient to almost entirely inhibit estrogen in the body. However, the draw back is that this one pill per day can cost you around ten dollars. The final conclusion about inhibitors is that these are far more powerful drugs then the ERA. All the drugs listed above effect a much wider hormonal spread then the anti-estrogens and they are also going to cost you a lot more.
Of all the drugs mentioned, I think that arimidex is the most useful drug for the body builder. Duchaine helped promote cytadren, particularly because of its anti-catabolic ability to suppress cortisol. But, even he acknowledged the double-edged sword that this drug was. Too little cortisol is painful to the joints and in the end, extremely dangerous. I would not recommend the use of cytadren, but I have provided the moderate dosage schemes.
I hate hearing that phrase clutched to First of all, there is no way of telling what your gains would have been like without nolvadex or clomid. The scientific evidence that gave rise to this whole dispute which I believe Duchaine had a hand in too is that in addition to its anti-estrogenic action requiring estrogen receptors ER and leading to growth arrest of breast cancers, studies have previously shown that the anti-hormone tamoxifen nolvadex is able to block EGF, insulin and IGF-I mitogenic activities in total absence of estrogens.
Thus the excessive use of anti-estrogens will actually result in a loss of some of the most anabolic of hormones insulin and insulin-like growth factor 1. Steroid antagonists can inhibit not only the action of agonist ligands of the receptors they are binding to, but can also modulate the action of growth factors by decreasing their receptor concentrations or altering their functionality.