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OTTAWA — While human growth hormone has a remarkable ability to generate controversy, exactly what it does for athletes, both good and bad, is as much of a mystery today as when it first found favor as a performance booster during the s. Galea has treated a number of elite athletes, including Tiger Woods, the sprinter Donovan Bailey and the swimmer Dara Torres, and is being investigated by American authorities for supplying performance-enhancing drugs to athletes in the United States.
Both Galea and his lawyer have strongly rejected that allegation and dispute the Canadian charges. Galea told The New York Times before being charged that he had never given an athlete growth hormone. But he acknowledged that he prescribed the drug to some patients at his Toronto clinic who were at least 40 and fatigued. Galea, 50, is such a believer in its restorative powers that he said he had injected the hormone into his body five days a week for the last decade.
But physicians and medical researchers who have studied people with medical conditions that lead to growth hormone overproduction said that available evidence suggested that athletes who cheat by using costly H. Rogol, a professor emeritus of endocrinology at the University of Virginia. Rogol also reviews requests to the United States Anti-Doping Agency from athletes seeking permission to use banned hormones for therapeutic treatments. Suspicions that athletes may be using growth hormone first surfaced in the s.
But at the time, the only source of the hormone was cadavers. Advances in genetics , however, allowed biotechnology companies to clone and market several hormones, including H.
Those products swiftly found an illicit following among athletes. The hormones came with a long list of side effects. Heavy and prolonged growth hormone use can lead to abnormal bone growth in the face, head, hands and feet. It is widely suspected, but not proved, that excessive H.
The United States determined that potential harm from H. No such ban exists in Canada. Its approved uses are not conditions common among professional athletes: When it came to doping, the new hormones had an attractive feature. Because they are clones of natural hormones, they were invisible to antidoping tests that relied on looking for chemical abnormalities in urine samples.
Although a blood test for H. Rogol said that it only worked if the test subject had injected H. Some of the cloned hormones unquestionably enhance performance. Erythropoietin, or EPO , boosts red blood cells, offering athletes in endurance sports significant gains in speed and endurance. View all New York Times newsletters. The possible gains from H.
Auchus said that it reduces body fat and increases lean muscle mass, which are desirable not just for body building, where growth hormone abuse is believed to be widespread, but in a variety of other sports, including cycling, where leanness boosts results.
But, like everything, there is debate about the full extent of that effect. Anecdotal evidence suggests that some athletes use H.
But Auchus and Rogol said that there was considerable research showing that such gains were modest. One key difficulty in determining what an individual performance-enhancing drug brings to an athlete, Rogol said, is that few people involved in doping use just a single treatment. That opens up the potential for complex interactions, both beneficial and harmful, between various drugs and treatment methods. There is speculation that growth hormone may be used in conjunction with platelet-rich plasma injections to swiftly heal injured muscles and tendons.
While Galea is a leading proponent of platelet therapy, he said during an interview that he never combined the technique with growth hormone. But there is considerable doubt about whether injecting H. Growth hormone does not act directly. Instead it prompts the body to produce insulin-like growth factor 1, or I. The overwhelming majority of I.
Evidence shows, however, that growth hormone can prompt local I. Auchus said that it was not clear if such local production was significant enough to accelerate healing.
Even platelet therapy, widely practiced on injured tissue, is an unproven treatment marked by uncertainties; it is however legal and not banned by the World Anti-Doping Agency.
A small amount of the substance is then injected into the damaged area. The belief is that the high concentration of platelets — 3 to 10 times that of normal blood — prompts the growth of new soft-tissue or bone cells.
Rodeo, who is also a physician for the New York Giants, said that Galea was far from unique in providing the treatment in North America. Tell us what you think. Please upgrade your browser. Newsletter Sign Up Continue reading the main story Please verify you're not a robot by clicking the box.
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