Haldol DecanoateHaldol, Haldol Decanoate, more Haloperidol LA, Peridol Classes: Lower initial doses and more gradual adjustments recommended; 0. Lower adult doses and longer haloperidol decanoate mechanism of action intervals recommended compared with typical adult doses. Lower initial doses and more gradual adjustments recommended; monthly dose times daily PO dose.
Haloperidol - DrugBank
Unfortunately, the therapeutic effects of HP also come with severe extrapyramidal side effects, resulting in movement disorders in patients. Olanzapine, a new atypical neuroleptic, seems to have better efficacy, with less severe adverse effects. There has been increasing evidence of the role of reactive oxygen species ROS and oxidative stress in the pathogenesis of Schizophrenia.
We therefore hypothesized that the differences between HP and Olz could be partly because of the differences in the oxidative stress they cause. We studied the pro-oxidant and antioxidant effects of these two drugs in vitro and examined the mechanism of their cytotoxicity in a neuronal cell model using PC cells. Olz on the other hand was found to scavenge hydroxyl radical at a rate of This was shown using the hydroxyl radical dependent deoxyribose degradation assay and EPR spin trapping methods.
HP was also found to quench singlet oxygen in a dose-dependent manner. At high concentrations mM each of these antipsychotic drugs caused a significant increase in cell death that was readily detectable by all the techniques. Light microscopy with trypan blue staining indicated that necrosis was the predominate form of cell death with both drugs.
Apoptotic cells were rarely observed by microscopy in vehicle or drug-exposed cells. Further, no increase in early cellular apoptosis was observed using the Annexin-V probe. These data, along with the cytologic evaluations suggest that cell death in PC pheochromocytoma cells exposed to HP or Olz may primarily be necrotic in nature, rather than apoptotic.
Because Olz at a low dose was less cytotoxic and was found to have lower pro-oxidant action than HP the secondary effects manifested in patients with chronic treatment with HP may, at least in part, be attributed to the pro-oxidant effects of the drug. Collections Masters Theses .