Mechanism of Steroid Hormone Action
You can change your ad preferences anytime. Show related SlideShares at end. Full Name Comment goes here. Are you sure you want to Yes No. Sekalembe Nasser , Student at Gulu college of health sciences. Embeds 0 No embeds. No notes for slide. If D decreases, A production is triggered, i. The water soluble hormone. They are poorly soluble in water. So they cannot be dissolved in watery blood. They bind to plasma protein and present in the blood in protein bound form. They are lipid soluble.
The lipid soluble hormones include thyroid hormone, steroid hormones and Vitamin D3 6. The hormonal response has got multiple steps, and each step multiplies the signal cascading effect that finally leading to million fold amplification, i. This process is known as signal amplification. Each receptor has specific binding region with hormone and another region with binding with DNA. Receptor alone cannot bind to DNA unless it binds to hormone. Once the hormone is bound to receptor, the hormone receptor complex binds to specific region of DNA known as Hormone response element HRE.
The hormone— receptor complex activates a membrane protein called a G protein. The activated G protein in turn activates adenylate cyclase. A protein kinase is an enzyme that phosphorylates adds a phosphate group to other cellular proteins such as enzymes. Phosphorylation activates some of these proteins and inactivates others, rather like turning a switch on or off. Different protein kinases exist within different target cells and within different organelles of the same target cell.
Thus, one protein kinase might trigger glycogen synthesis, a second might cause the breakdown of triglyceride, a third may promote protein synthesis, and so forth. For example, some of the kinases unleashed when epinephrine binds to liver cells inactivate an enzyme needed for glycogen synthesis. The message then is passed to the cell where second messenger triggers appropriate cellular changes You just clipped your first slide!
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