Gynecomastia: A Dude Grows Breasts – Estrogen Side Effects of Male Anabolic Steroid UseThe topic of Estrogen is a very interesting estrogen related side effects steroids, especially as it pertains to anabolic steroid users, as it is one relatec the central aspects of anabolic steroid use, particularly where side effects are concerned. But this article is designed to be an all-encompassing informative piece on Estrogen in general as it relates to anabolic steroid use. Estrogen also called Oestrogen in some countries, particularly in Britain and in countries that use British Kortikosteroid oral untuk anak is a group of organic sode compounds that are of particular importance in female physiology, particularly in the menstrual and estrogen related side effects steroids cycles of females. Although Estrogens are steroid hormones, they are not anabolic steroids in the sense that they do not have any direct facilitation of muscle anabolism. In fact, steroirs majority of steroid hormones, like Estrogen, have nothing to do with muscle building.
Steroids to Treat Arthritis: Side Effects of This Treatment
The potential side effects associated with anabolic steroid use is a very prominent topic amongst not only athletes and bodybuilders , but also among individuals that do not hold any involvement what so ever in athletics or fitness.
Most usually, the first question an individual will have when confronted with the topic of anabolic steroids is: It is a very rich, dense, and vast topic that could be discussed for days on end. This particular article will deviate from the typical scare tactics so very common of the mass media and governments, and instead focus on the proper context under which anabolic steroids side effects should be viewed upon: The sensationalist and biased mass media would have us believe that anabolic steroids are extremely high-risk drugs that are the cause of acute death as well as long-term death.
This could not be farther from the truth, as the medical establishment regards anabolic steroids as low-risk therapeutic compounds with a high degree of safety. Regardless, a nabolic steroids can and do present various side effects, but these side effects must be viewed upon in the proper context rather than the extreme sensationalist and biased manner that the mass media and governments utilize in order to scare the population away from these substances.
When it comes to the issue of context, a perfect example is real world data in the form of clinical studies that have demonstrated that the frequency of side effects experienced by anabolic steroid users was that of The truth is that the figure of One must always keep this in mind in regards to such a topic that is so vast, diverse, and dynamic. It is first very important to remind the reader not to paint an image of anabolic steroids side effects with a single large brush.
This means that blanket statements must not be made concerning side effects and how they affect individuals. The dynamic of steroids side effects is so complex and diverse that every effort must be taken to clarify the common rumors, misconceptions and blanket generalized statements in regards to the side effects of anabolic steroid use.
Side effects resultant from anabolic steroid use can be split into three distinct and different categories:. General side effects 2. Male-specific side effects 3. Furthermore, only the most common anabolic steroids side effects that are shared among all anabolic steroids will be covered in this article.
There also exist a small number of anabolic steroids that possess side effects unique to them that are not shared with most other anabolic steroids — these will not be covered here. It must be first understood that anabolic steroids are hormones that affect and control several different functions and aspects of the human body and that its effects are very diverse.
Before delving into the different side effects, the following points must be made clear to the reader:. Genetics — Every single individual will respond in a different manner to any chemical, compound, anabolic steroid, food or drug in existence.
Because one person may experience a particular side effect or various side effects, it does not mean that another individual will experience the exact same thing. Each person is governed by a blueprint or a list of rules as to how he or she will respond to almost anything, and these blueprints are known as genetics, or DNA. Various genetic responses to certain stimuli, food, drugs, or even general experiences can and do also change over time.
Dose and duration — Increased doses most usually result in increased incidences and severity of side effects. It is very possible for certain individuals to possess a higher tolerance to various compounds and would be able to, for example, run ridiculously high doses of 2,mg weekly of an anabolic steroid and experience no ill side effects, while other individuals may run mg weekly of the same anabolic steroid and find they possess a high sensitivity and experience a plethora of different side effects such as gynecomastia , bloating , acne , etc.
Duration is also a very influential factor, as it need not be explained that the longer a particular anabolic steroid is utilized, the increased incidence of side effects will also present themselves as the duration of use becomes longer and longer. Age — Related to genetic response changing over time, age is a very important factor as to whether or not an individual will experience a side effect and how severe it will be.
For example, various individuals may be able to run aromatizable anabolic steroid cycles with no aromatase inhibitor or Estrogen blocker and experience no gynecomastia symptoms.
Type of anabolic steroid or compound used — There exist hundreds of different anabolic steroid analogues and compounds for the purpose of performance and physique enhancement. Many of them possess different attributes, capabilities, and properties some distinctly so more than others and therefore different side effects can result with varying intensities.
These are important hormones essential for proper healthy function of the human body, and they govern, affect, and control a myriad of different functions and aspects of the human body. These hormonal effects are so dynamic in nature that it is considered a very poor demonstration of intelligence to relegate the effects and side effects of anabolic steroids to simplistic views in which an individual generalizes steroids side effects, and generalizes such a topic.
What will be covered here are the most prominent general steroids side effects. This refers to the potential side effects that are not gender-specific and can and will affect all genders of all age groups equally.
When anabolic steroids are utilized at the doses required for physique and performance enhancement also referred to as bodybuilding doses , all anabolic steroids can and do have negative effects on the cardiovascular system of the human body. The degree and severity by which these negative cardiovascular changes occur is dependent on which anabolic steroid is used some exhibit more of a negative effect while others do not, and some even exhibit improvements , dose, duration of use, personal response, and age.
Many of these negative cardiovascular effects can be offset with proper nutritional adjustments. The fact of the matter is that the majority of cardiovascular effects resultant of anabolic steroid use is short-term and reversible.
Heart attacks and strokes as a result of solitary anabolic steroid cycles are extremely rare. However, excessive abuse of these drugs in both high doses as well as excessively long cycles and periods of use can contribute to a long-term accumulative effect where an increased risk in the long-term is a possibility.
These cardiovascular steroids side effects include: All anabolic steroids exhibit negative cholesterol profile changes in the body to varying extent some exhibit this more and some less. The result of such changes involves an increased risk of arteriosclerosis, and the degree to which these changes occur for the worse are usually dose-dependent with higher doses increasing the negative changes and the risks.
Other factors that affect these negative cholesterol changes are: This is where oral anabolic steroids hold a negative reputation for exhibiting a far worse negative impact on cholesterol in comparison to injectable anabolic steroids. This is because the liver serves to function as the cholesterol processing center for the human body, and the increased hepatotoxicity associated with anabolic steroids will result in even worse negative cholesterol changes.
The manner by which these changes occur involves the effect of androgens on hepatic lipase. Hepatic lipase is an enzyme located in the liver which is responsible for the breakdown of HDL good cholesterol .
It then stands to reason that a reduction in hepatic lipase would result in lower HDL cholesterol levels as this enzyme works to reduce blood plasma levels of HDL cholesterol. Logic might then indicate that as the doses of anabolic steroids increase, this effect too increases in relation to dose.
However, this is wrong! However, when the dose in the same study was increased to mg weekly, there were no additional reductions in HDL cholesterol, which would indicate that there seems to be a ceiling limiting how much hepatic lipase enzyme activity can be stimulated by anabolic steroids. At the same time, various other anabolic steroid analogues have been found to exhibit far greater negative cholesterol changes even at lower doses, and it has been previously mentioned that oral anabolic steroids that are Calpha alkylated tend to exhibit a far greater effect on the negative changes associated with cholesterol.
Calpha alkylation also known as methylation is a chemical modification required to allow an anabolic steroid to become resistant to hepatic metabolism in order to allow high bioavailability of the anabolic steroid through oral administration.
This chemical modification also results in increased hepatic strain. One particular study compared the effects of oral Stanozolol Winstrol to Testosterone on cholesterol profiles, where mg weekly of Testosterone was administered in comparison to 6mg per day of oral Stanozolol .
The conclusion here is that oral steroids are far more strenuous to the cardiovascular system in this case than injectable non Calpha alkylated compounds. Estrogen itself is actually known to have positive effects on cholesterol profiles, improving HDL levels and reducing LDL as well. The issue of concern here is the use of ancillary compounds known as aromatase inhibitors during anabolic steroid cycles to the extent whereby circulating Estrogen levels are reduced to sub-physiological levels which is not a good thing.
Testosterone in particular has demonstrated in one clinical study to have only a mild impact on HDL cholesterol after a 12 week period where mg of Testosterone Enanthate was administered weekly. Estrogen levels should always be controlled and maintained as closely as possible to normal physiological levels. This must be remembered by any potential anabolic steroid user in that Estrogen levels must be closely monitored so as to ensure they are not reduced to the point whereby cholesterol profiles are impacted negatively even further.
Proper attention to a clean diet and the inclusion of various healthy cholesterol promoting foods such as omega-3 fatty acids and fish oils at least 2 — 4 grams per day is essential while on a cycle of anabolic steroids in maintaining healthy cholesterol profiles during cycles, which indeed can be done. The cholesterol changes mentioned as a result of anabolic steroid use are always temporary and always return to normal following cessation of a cycle.
This is why it is advised that individuals perform anabolic steroid cycles in the range of 8 — 12 weeks with at least 4 months of a break in between each cycle.
Such a protocol should effectively eliminate any risks of long-term accumulative changes in the arteries. Continuous use without breaks is most usually the cause of severe long-term buildup of cholesterol resulting in arteriosclerosis especially if oral anabolic steroids are utilized for extended periods.
The fact of the matter is that males naturally manufacture far more Testosterone endogenously than females do, and it has been demonstrated that males on average possess larger hearts than do females . Types of training also affect the differences in the types of heart enlargement:.
This type of exercise stimulus causes what is known as concentric remodeling, which refers to the thickening of the ventricles outer wall of the heart but no growth of the internal wall. Aerobic exercise endurance training: This type of exercise stimulus causes what is known as eccentric remodeling, which is characterized by the growth of the internal wall of the heart but no growth of the ventricles outer walls. Despite the different variations in heart growth, it is common knowledge that no disruption in actual heart function has ever been observed, indicating that these changes do not affect proper heart function diastolic function.
Furthermore, the heart muscle adapts according to the level of exercise stimulus provided. This means that when training and exercise is halted, the heart will, after a certain period, begin to decrease in size and revert back to a smaller size. This is a typical characteristic of all muscle tissue whereby if the exercise stimulus is halted, muscle atrophy will eventually occur.
Anabolic steroid use in particular does increase the probability for the enlargement thickening of both ventricular walls of the heart left and right ventricles . However, it is the left ventricle which has been observed in anabolic steroid users to exhibit a larger increase in muscular size . Remember that these same changes are found in steroid-free athletes as well, but it is in anabolic steroid using athletes where the size increases of the heart muscle is observed as being greater than those of steroid-free athletes.
An interesting note in the differences here is that anabolic steroid using athletes who have left ventricle growth beyond a certain point have exhibited impaired heart function and efficiency . The degree to which the heart muscle will experience significant growth changes has been found to be directly related to the doses used, where higher and higher doses of anabolic steroids will often result in greater growth of cardiac tissue.
The size of the heart has also been found to shrink or grow depending on the habits of the anabolic steroid user. For example, not only does dose and duration of use determine the size of growth of the heart muscle, but the heart will also shrink in size over time when anabolic steroids are discontinued .
In general, the subject of heart growth and whether or not it is actually a benefit to the athlete or a detriment is an ongoing investigation and debate in the field of sports medicine. Blood pressure elevations are a possibility of steroids side effects, but this tends to occur only in certain select situations and conditions.
First and foremost, blood pressure increases are commonly the result of increased water retention caused by increased Estrogen levels as a result of aromatizable androgens being aromatized into Estrogen by the aromatase enzyme. Water retention and bloating often causes blood pressure increases due to the increased fluid retention both extracellular and intracellular, and imposes increased pressure on the arterial walls. This side effect can effectively be eliminated by either the use of anabolic steroids that do not convert into Estrogen, or through the use of an aromatase inhibitor compounds such as Aromasin, Arimidex, and Letrozole that serve to disable the enzyme responsible for the conversion of androgens into Estrogen: With a large percentage of these enzymes effectively disabled, Estrogen conversion will grind to a halt and total circulating blood plasma levels of Estrogen in the body will drop, as will the water retention caused by the Estrogen, and subsequently the heightened blood pressure will reduce as well.
The majority of blood pressure elevations in anabolic steroid users have been found to be moderate rather than extreme or severe.
There are other factors in addition to the cause of Estrogen and water retention that cause blood pressure increases in anabolic steroid users. However, the primary means of blood pressure increase is that of either excessive Estrogen conversion, or a poor diet that is too rich in sodium and simple carbohydrates.
Blood pressure can be maintained and kept well into the normal or even impressive range in anabolic steroid users that take care to avoid large Estrogen increases, as well as maintaining a very clean low to moderate sodium content diet without any simple sugars or carbohydrates.
Polycythemia is a condition in which an individual possesses a red blood cell count that is excessively high above the normal range.
This is very common in all athletes, especially endurance athletes. Increased physical demands caused by regular training and exercise result in an increased demand for oxygen transport to the muscles. The result is an increase in red blood cell production, as red blood cells are responsible for oxygen transport in the body. Hemoglobin is the protein located in the center of red blood cells, which is the protein that oxygen binds to so that it may be carried by the red blood cell to tissues that require oxygen.