Proviron (Mesterolone)If this is your first visit, be sure to mseterolone before you can mesterolone hepatotoxicity Registering gets you access to free supplement samples and special email hepatoroxicity for forum members only. Results 1 to 3 of 3. Those both act very similarly in mechanism to Proviron, but mesterolone hepatotoxicity more accurate way to think of this compound is as something like "Oral Masteron. Remember, DHT is 3 to 4 times mesterolone hepatotoxicity androgenic as testosterone and is, of course, incapable of forming estrogen.
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If this is your first visit, be sure to register before you can post: Registering gets you access to free supplement samples and special email sales for forum members only. Results 1 to 3 of 3. Those both act very similarly in mechanism to Proviron, but a more accurate way to think of this compound is as something like "Oral Masteron.
Remember, DHT is 3 to 4 times as androgenic as testosterone and is, of course, incapable of forming estrogen. Also, Proviron is quite unique in that a simple look at its 4-ring structure will show us that it is not going to be too liver toxic, since it is not cAlpha-Alkylated, as many orals are and this modification lacking in Proviron makes drugs more liver toxic.
Proviron has a 1-metyhl group added, instead. Looks pretty great on paper, right? Well, as usual, things tend to look better on paper than they do in the body.
Your body has a negative feedback loop which prevents your body from having too much DHT floating around if youve been paying attention up to now from reading my other stuff, you already know this. An excess of DHT will eventually be changed into another largely not anabolic compound. And of course, being a DHT-based compound, Proviron isnt going to be great for female athletes to use. Virilization development of male sexual characteristics is going to be a concern for women daring enough to try this stuff.
My advice is that there is much better, safer compounds for female athletes and bodybuilders to use. So lets go back to the comparison with being some sort of "Oral Masteron" basically since Proviron is 5-alpha reduced and not capable of forming estrogen, and also has a very high affinity for binding to the aromatase enzyme the enzyme responsible for converting all that good testosterone in your body into all that nasty estrogen.
Also, Id like to note that Proviron bound to the Anabolic Receptor better than any oral anabolic except for the insanely toxic MethylTrienolone , having an ability to bind to the AR better then testosterone, but not as well as Nandrolone 1. Unfortunately, as we know, DHT also has a high affinity for binding to receptors in the scalp and prostate, causing some possible nasty side effects, like male pattern baldness and prostate enlargement. Its important to remember that DHT and DHT derived compounds are used quite successfully to treat gynecomastia, and in this area, Proviron is no different.
Lets delve into some of the positive points of this drug before we go any farther. Androgen Receptors are found in fat cells as well as muscle cells 5 , and while they act on the AR in muscle cells to promote growth, they also act directly on the AR in fat cells to affect fat burning.
R, the higher the lipolytic fat burning effect on adipose fat tissue 6 2. As if thats not enough good news, some steroids notably, testosterone even increase the numbers of A. Thus, if you are taking a simple stack of proviron and testosterone, you'll have more of the test you shoot as free testosterone floating around building muscle compliments of the Proviron , more androgen receptors to be bound to compliments of your testosterone by your Proviron, thus causing more fat loss.
Testosterone and Proviron are a very nice synergistic stack, pretty nearly an "ideal" stack of an oral and injectable, because both drugs will actually act to enhance the effect of the other.
So what we have here is a steroid which can basically make other steroids more effective by preventing their conversion into estrogen, as well as increasing the amount of circulating free testosterone in your body. This of course all provides a more hardened and quality look to muscles. Proviron is very much a "synergistic" drug in this respect, and its inclusion in any cycle would definitely make all of the other steroids perform better, and provide better gains.
This is all compounded by the fact that proviron is a very lipolytic fat-burning drug. Thus, by not suppressing those hormones and maybe even raising some, your normal testosterone levels will remain intact. This points to a novel use for this compound during Post-Cycyle-Therapy for a non-suppressive "bridge" between cycles. Unfortunately, this stuff is not too hot on its own. Its a good drug for inclusion in a cycle containing testosterone and other armoatizable steroids, and its a good drug for a possible "bridge" between cycles.
Alone, however, as an androgenic or anabolic agent, its effects have been very weak in both studies 9 , as well as in the experience of everyone I spoke to about it. This may be due to the addition of the 1-methyl-group to DHT, which makes this stuff orally active. Whatever the case, as a stand alone anabolic or androgenic compound, its not too impressive. Proviron Proviron Mesterolone Profile [1 alpha-methyl beta-hydroxy-5 alpha-androstanone] Molecular Weight: Relative binding affinity of anabolic-androgenic steroids: Xu X, et al.
The effect of mesterolone on sperm count, on serum follicle stimulating hormone, luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic men. Int J Gynaecol Obstet. The effects of mesterolone, a male sex hormone in depressed patients a double blind controlled study. Methods Find Exp Clin Pharmacol.
Proviron Mesterolone by Bill Roberts — Proviron mesterolone is an interesting anabolic steroid, though it is not of much value to bodybuilding. It seems that the most common reason for many to consider including it in a steroid stack is for anti-estrogenic activity.
In the days before anti-aromatases and the use of SERMs selective estrogen receptor modulators such as Clomid and Nolvadex, there was some merit to this. An amount of aromatizing steroid marginally over the amount that would be tolerable without Proviron became tolerable with the inclusion of it. However, the effect is indeed only marginal, and much better anti-estrogenic agents now exist. When these are used, there is no need for Proviron as an anti-estrogen.
The mechanism by which it has some effectiveness in this regard is from binding weakly to the estrogen receptor without activating it, and to the aromatase enzyme.
In the first case, this partially reduces the number of receptor sites momentarily available to bind estrogen, thus reducing estrogenic activity. In the second case, some fraction of aromatase molecules at any given moment are unavailable to bind and convert testosterone, their binding sites being occupied with mesterolone. The second most common reason is probably to address a fear that libido might be lost without it.
It is true that when added to normal androgen levels, Proviron has an androgenic effect that in many cases improves libido. However, most anabolic steroids also have this same property. In a steroid cycle, adding Proviron accomplishes nothing further.
Or in the case of anabolic steroids such as nandrolone Deca which for other reasons may adversely affect libido, Proviron provides no greater help against that than do various other anabolic steroids. One of the interesting things about Proviron is that while it assays tests as being an effective anabolic in the rat, it is virtually useless for building muscle in man.
This may be due to enhanced conversion in muscle tissue to the diol, but it may instead be due to some unknown reason. Another interesting thing is that it enjoys some practical use as a pro-sexual agent in between cycles.
Typically 50 mg is taken shortly before improved performance is expected to be useful. Using it during the recovery phase as part of post-cycle therapy is counterproductive. It is also inadvisable for this reason to use it continuously while intending to be off-cycle, but occasional recreational use presents no problem.
Proviron has been used in female bodybuilding, but it has almost undoubtedly the worst ratio of anabolic effect to virilizing effect of any anabolic steroid in common use. Most of that value is from anti-estrogenic effect, which Nolvadex can also accomplish. And for an androgen component, there are better choices, including Primobolan.
Unlike almost all other orals, Proviron is not hepatotoxic, as it is not alkylated. Tablets are typically 25 mg, and taken one or two at a time. Amounts greater than this have no further effect on improving libido off-cycle, but if used for a specific occasion, whether on-cycle or off-cycle, may temporarily improve vascularity, if it is already noticeable but has room for improvement. Mesterolone is the chemical name of active ingredient in Proviron.
Just as with DHT, the activity of this steroid is that of a strong androgen which does not aromatize into estrogen.
In clinical situations Proviron is generally used to treat various types of sexual dysfunction, which often result from a low endogenous testosterone level.
It can usually reverse problems of sexual disinterest and impotency, and is sometimes used to increase the sperm count. The drug does not stimulate the body to produce testosterone, but is simply an oral androgen substitute that is used to compensate for a lack of the natural male androgen. Although this steroid is strongly androgenic, the anabolic effect of it is considered too weak for muscle building purposes.
This is due to the fact that Proviron is rapidly reduced to inactive metabolites in muscle tissue, a trait also characteristic of dihydrotestosterone. The belief that the weak anabolic nature of this compound indicated a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle building steroids, should likewise not be taken seriously.
In fact due to its extremely high affinity for plasma binding proteins such as SHBG, Proviron may actually work to increase the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes Proviron is primarily used as an anti-estrogen.
It is believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex though less profound , the drug acting to prevent the buildup of estrogen in the body. This is in direct contrast to Nolvadex, which only blocks the ability of estrogen to bind and activate receptors in certain tissues.
The anti-aromatization effect is preferred, as it is a more direct and efficient means of dealing with the problem of estrogenic side effects. Another disadvantage of Nolvadex is that if discontinued too early, a rebound effect may occur as high serum estrogen levels are again free to take action. This of course could mean a rapid onset of side effects such as gynecomastia.
Most actually prefer to use both Proviron and Nolvadex, especially during strongly estrogenic cycles. With each item attacking estrogen at a different angle, side effects are often greatly reduced. The anti-estrogenic properties of Proviron are not unique to this compound. A number of steroids have in fact demonstrated similar activity. Dihydrotestosterone and Masteron 2methyl-dihydrotestosterone for example have been successfully used as therapies for gynecomastia and breast cancer due to their strong anti-estrogenic effect.
It has been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion the most active site of nandrolone aromatization seems to be the liver. The anti-estrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme.
With the aromatase enzyme bound to the steroid, yet being unable to alter it, and inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones. This is especially beneficial when anabolics like Winstrol, oxandrolone and Primobolan are being used alone, as the androgenic content of these drugs is relatively low.
Proviron can supplement a well needed androgen, and bring about an increase in the hardness and density of the muscles. Since this is such a strong androgen however, extreme caution should be taken with administration. Higher dosages clearly have the potential to cause virilization symptoms quite readily.
For this reason females will rarely take more than one tablet per day, and limit the length of intake to no longer than four or five weeks. One tablet used in conjunction with 10 or 20mg of Nolvadex can be even more efficient for muscle hardening, creating an environment where the body is much more inclined to burn off extra body fat especially in female trouble areas like the hips and thighs.
The typical dosage for men is one to four 25 mg per tablets per day.