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Profiles of Oral and Injectable Steroids: Evolutionary Factor Ebook - Chapter 6 - jmhw.info
This chapter is about some of the most popular steroids, both orals and injectables. This is to supply users with must-know background info about these drugs with the aim of providing an informative and safety guideline on steroid use. Let's start by talking about the difference between the two types of steroids — the orals and the injectables. The following is a discussion of the assets and drawbacks of oral steroids and the injectable versions.
The basic difference between these two types is that orals are active and ready in the pill so that the body can use them while the 17AA is still attached. Injectables that have esters with the exception of Winstrol that does not have an ester are not active and cannot be readily used by the body, not until the liver enzymes cleave cut the ester chain off. It is only then that the steroid can and does work in the body. Eventually, it gets broken down metabolized by the liver.
The ester chain's placement interferes with the anabolic steroid docking in the cell's androgen receptors, and need to be removed before the anabolic can dock at the receptor sites or be broken down by the liver. The 17AA of orals do not interfere with docking at the cell receptor sites and will allow the hormone to dock with the Androgen receptor without modification.
Oral steroids have relatively shorter active lives, thus they are excreted rather quickly from the body. The removal of a drug from the plasma is called clearance. Oral steroids tend to have shorter active lives maximum is hours than esterified injectables minimum of one day to a maximum of 18 days and also have quicker clearing times. So orals are the choice if an athlete wants to avoid detection during testing.
Injectables are less popular in this regard because they have 'easier' detectability as they tend to stay for longer periods in the body. The only injectable that has found use for drug tested athletes is Testosterone Suspension, which is a water based form of Testosterone that contained no ester or methyl group. Injectable steroids tend to have less negative effects than orals, causing less liver toxicity than their oral counterparts.
What makes injectables safer than orals? When you ingest something orally — be it food or drugs — the bulk of the ingested substances pass through the liver before entering the bloodstream.
The primary goal of this process — called the first pass metabolism — is to filter toxic materials from circulating into the general system. How does this process work? Detoxification or deactivation in the liver typically involves one or several hydroxyl groups -OH primarily to improve the water solubility of molecules, thereby making excretion in the urine more easily accomplished.
Oral steroids have to undergo chemical modification to survive the deactivation of the liver. The c alpha-alkylation improves the efficacy of the oral steroids, but it is known to cause stress to the liver.
This alteration is absent with injectables, hence if steroids are administered intramuscularly, they are considered degraded in just a single pass through the liver. Profiles of Oral Steroids: First introduced by the drug lab Syntex in the 's, Anadrol 50 is the US brand name of the compound oxymetholone. This drug is considered to be a very potent oral androgen. Since it elevates red blood cell production, a characteristic inherent in the majority of the AAS products, it used to be a promising compound for treatment of anemia.
However, newer products which promote RBC production replaced Anadrol for this purpose. Particular example of these new drugs is Epogen, a non-steroidal hormone that positively affects erythropoietin.
Consequently, Anadrol was discontinued by its manufacturer in because if financial considerations. Nevertheless, the interest for this drug has been revived since because of its potential as an anti-wasting agent specifically in AIDS cases. In the case of Athletes and Bodybuilders, extreme effects would best describe how Anadrol works. Considered to be the most powerful of all steroids currently available in the market, it can give its user impressive results.
A tab or two a day in less than six weeks can yield 20 to 30 pounds of muscle. Novices are overly satisfied when they report they gain up to a pound a day during their first three weeks of use.
Plus, there are the strength gains which are massive compared to any other steroid. It is no wonder that despite the claim that Anadrol is one of the most dangerous orals around, it is still one of the most sought after drugs. Oxymetholone is DHT-derived and it does not aromatize. This means that it does not convert to estrogen. However, Anadrol does cause estrogen-like side effects, most common of which are bloating and Gynecomastia.
These side effects are proving to be a puzzle to many Anadrol users and experts because if this drug does not aromatize, so what is causing the estrogen side effects?
Opinions on this have been divergent, to say the least. Some say that the effects are due to its progestational activity. This may hold water because estrogens and progestins basically display the same effects. However, medical studies say otherwise. One such study conducted research on different steroids, including oxymetholone, and it came up with this result — there is no significant progestational activity on this particular compound.
The estrogen side effects can be then attributed to the intrinsic ability of oxymetholone to directly activate the estrogen receptor without its structure itself being changed.
As such, stacking Anadrol with reductase inhibitors such as Finasteride to minimize its androgenic effects particularly male pattern baldness is a waste of money because of the non-aromatization and the noninvolvement of the 5-alpha reductase enzyme.
There is, however, the need to avail of estrogen receptor antagonists, such as Nolvadex and Clomid, to counter estrogenic side effects. Another plausible theory why the use of Anadrol is allegedly causing gynecomastia one of the most dreaded effects of aromatization is because users have purchased counterfeited versions that contained methyltestosterone.
The main deterrence to Anadrol use is its 17 alpha-alkylation, a characteristic inherent in most oral steroids. This chemical transformation is necessary for orally administered drugs to survive the detoxification activity of the liver. Same transformation is also the usual threat to the integrity of the liver.
Anadrol has gained a reputation of being very harsh on the liver, more toxic than other oral steroids. Since Anadrol's effective dose is 50mg and some bodybuilders will take as much as mg, there is a greater amount of hormone passing through the liver causing damage.
It is important to outline here that you to have to take a relatively higher dosage when you're using Anadrol. This is because the drug has a lower affinity to androgen receptors ARs. When you compare Anadrol to other steroids, like Dianabol and oral Winstrol which are also cAA , you'll get a picture of how significant the difference in dosage is. Both D-bol and Winstrol have higher affinity with ARs, and therefore do not require high dosages. With Winstrol you can have an effective dosage of 15 to 25 mg daily intake.
With Anadrol, you need to ingest 50 mg per day to see ideal results, and maybe triple that amount to see exceptional gains. This is probably why Anadrol is said to be highly stressful to the liver because its effective dose is 50 mg.
With other oral steroids the typical dosage only ranges from 5 mg. Although the action of the steroid itself on the AR is weaker milligram per milligram, the damage to the liver by the 50 mg. To combat bloating, the technique found most effective is to use herbal flushes and take in more water. Adding Winstrol to an Anadrol cycle can also counter most of Anadrol's negative effects. Other positive effects of Winstrol when taken in conjunction with Anadrol are the decrease in joint-arthritic tension, and inhibition of estrogen-like side effects like gyno, as may be caused by Anadrol itself.
In many ways, Winstrol can be considered as 'anti-Anadrol' since it prevents many of Anadrol's side effects. Thus, for a person who is prone to such negative reactions, it is ideal to stack Anadrol with Winstrol. Anadrol users are cautioned against taking more than three 50 mg tablets a day and therapy must not exceed six weeks. However, when stacked with another injectable that can aromatize, Anadrol use should be kept to less than 4 weeks.
Regular examination of your liver and kidney functions should also be carried out. The kidneys can be affected because of water retention. Since this steroid is derived from DHT, it can cause problems in DHT-sensitive areas such as the scalp, skin and prostate. Another concern is its effect on the HPTA hypothalamic pituitary testicular axis which can result in a decreased sperm count. Also, sperm and natural testosterone levels can normalize after two to three weeks of discontinued use.
Discontinuance, however, can also pose some problems. Since on-cycle use of Anadrol produces extreme gains, cessation of use can induce extreme loss in body weight. This is due to the fact that what you have gained is mostly intramuscular water retention, and after discontinuance water retention is immediately diminished. For a less dramatic crash, some advice to shift for milder drugs like Deca, which can retain the gained muscle mass.
Ancillary drugs are a must to avoid possible side effects. Bodybuilders and Athletes can source out Anadrol from the black market as well as from legally-established labs. Counterfeits are also in wide circulation and again always be cautious of dubious versions.
Kanestron is a veterinary version of this compound. Some Mexican Veterinarian versions of Anadrol are 75 mg. To avoid serious estrogen-like side effects the user must make sure to use ancillary drugs when taking this drug. Anavar was developed by the G. Dianabol was the reigning steroid during that time.
Dismal commercial performance may be the reason why Searle ceased the production of this drug in During the 's the reputation of steroids as therapeutic drugs has begun to wane partly due to prevalent abuse of these drugs and to the emergence of nonhormonal medications.
As a consequence, prescriptions of these drugs began to decline. When Bio-Technology General BTG bought the rights to manufacture this drug, with the brand name Oxandrin, Anavar cultists could not help but feel ecstatic about this development. Read on to find out why. Among the numerous AAS currently available, Anavar is one among those at the top of the list for several reasons.
It boasts of several advantageous characteristics that are not found in most drugs. It is considered a mild steroid; i. It does not aromatize; that is, it does not convert to estrogen so it won't cause gynecomastia; and, when taken in low dosages, it does not interfere with the body's testosterone production.