Masteron Side EffectsDrostanoloneor dromostanoloneis an anabolic—androgenic steroid Anivar polovina of drostanolone study dihydrotestosterone DHT group which was never marketed. Drostanolone and its ester drostanolone propionate were first described in From Wikipedia, the free encyclopedia. Elks 14 Drostanoloone The Dictionary of Drugs: Chemical Data, Structures and Bibliographies. Journal of the American Chemical Drostanolone study.
Drostanolone - DrugBank
Drostanolone also known as dromostanolone is a potent synthetic androgenic anabolic steroid similar to testosterone. Drostanolone is indicated in postmenopausal women with recurrent breast cancer, in a combined hormone therapy.
For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Dromostanolone is a synthetic androgen, or male hormone, similar to testosterone. Dromostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes.
This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production. Side effects include virilization masculine traits in women , acne, fluid retention, and hypercalcemia.
Patent 3,,; January 21, ; assigned to Syntex Corporation, Panama. Drostanolone Targets 1 Enzymes 1 Carriers 1 Biointeractions 2. Eli lilly and co. General Function Zinc ion binding Specific Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Assignment of anabolic-androgenic and antiandrogenic properties to some chlorine-substituted steroids on the basis of their binding characteristics to the androgen receptor of the rat seminal vesicle.
Endocrinological and pathological effects of anabolic-androgenic steroid in male rats. Masculinization of the European sea bass Dicentrarchus labrax by treatment with an androgen or aromatase inhibitor involves different gene expression and has distinct lasting effects on maturation. Epub Oct General Function Androgen binding Specific Function Functions as an androgen transport protein, but may also be involved in receptor mediated processes.
Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone How many drug targets are there? Nat Rev Drug Discov.
Drugs, their targets and the nature and number of drug targets.