Studies suggest that CBD oil could play a role in treating arthritis and CBD oil is the oil derived from hemp, which is a type of cannabis A study found that the topical application of CBD had the potential to relieve pain. However, CBD oils do not contain THC, the compound in marijuana that makes you “high. A review of the use of CBD to treat chronic pain similarly concluded favorite lotion and apply it directly to your skin to help with stiff, achy joints. But which format is more effective at treating pain? Both CBD and THC - another cannabinoid found in high levels in the cannabis of pain, including arthritis and joint pain, inflammation, muscle spasms, muscle soreness.
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The first-line therapy used to treat OA pain is nonsteroidal anti-inflammatory drugs; however, with long-term use their efficacy declines and they can lead to major adverse gastrointestinal and cardiovascular events.
Historically, OA has been classified as noninflammatory arthritis; however, there is now overwhelming evidence that synovitis can occur in response to pro-inflammatory mediators being released into the joint.
The endocannabinoid system ECS plays an important physiological role in the regulation of tissue inflammation and pain. Immunohistological and pharmacological evidence confirm that cannabinoid 1 CB 1 and cannabinoid 2 CB 2 receptors are expressed on the neurones and microvasculature that supply rat knee joints.
Cannabidiol is the main noneuphoria producing component of the cannabis plant. The initial aim of this study was to assess the effect of locally administered CBD on joint pain in animals with end-stage OA.
Since acute inflammation can contribute to the long-term development of OA joint pain, 32 the ability of CBD to reduce acute OA synovitis and prevent the subsequent progression of persistent OA pain was also investigated.
After arrival at the animal care facility, all rats were permitted at least 1 week to acclimate to their environment. Animals were housed in pairs, cages were lined with woodchip bedding, and animals were provided with environmental enrichment. Standard laboratory chow and water were provided ad libitum. All experimental protocols were approved by the Dalhousie University Committee on the Use of Laboratory Animals, which acts in accordance with Animal Research: The knee was then manually extended and flexed for 30 seconds to disperse the solution throughout the joint.
The left carotid artery was cannulated to allow for continuous measurement of the mean arterial blood pressure. A specialised clamp was fixed to the mid-shaft of the isolated right femur and attached to a stereotaxic frame to prevent movement of the proximal aspect of the rat hind limb. The right hind paw was then placed in a shoe-like holder that was connected to a force transducer and torque meter Data Track R; Intertechnology, ON, Canada to standardise the amount of rotational force being applied to the knee joint.
The medial articular branch of the saphenous nerve was isolated and transected in the inguinal region to prevent spinal reflexes. The epineurium was removed and the nerve teased to isolate fine neurofilaments which were then placed on a platinum recording electrode to measure single-unit activity.
To identify a joint afferent fibre and its receptive field, the knee joint was gently probed with a blunt glass rod. The mechanical threshold of each recorded joint afferent was determined by gradually increasing the torque applied to the joint until the fiber elicited an action potential. The conduction velocity of the fibres were determined by electrically stimulating the receptive field with a pair of silver bipolar stimulating electrodes 0.
The mechanosensitivity of the joint fibre was assessed by applying noxious outward rotations to the knee and counting the number of action potentials elicited during the rotation. Noxious rotation refers to torque occurring outside the normal range but not severe enough to cause soft tissue injury.
On day 14 post-MIA induction, 3 sets of noxious rotations, each lasting 5 seconds, were applied 5 minutes apart as a baseline measurement of afferent activity.
To minimise the use of animals, multiple doses of CBD or vehicle were assessed in each fibre. A washout period of at least 50 minutes was observed between the administration of varying doses of CBD or vehicle to allow afferent firing to return to baseline levels. The percentage change in afferent activity before and after administration of CBD or vehicle was calculated offline using Spike2 software Cambridge Electronic Design, Cambridge, United Kingdom.
All recorded fibres fired in response to close i. Von Frey hair mechanosensitivity was used as a measure of secondary allodynia. Alert, unanaesthetised animals were placed in a Plexiglas chamber with a metal mesh flooring which allowed access to the plantar surface of each hind paw.
After allowing the animal to acclimate until exploratory behaviour ceased approximately 10 minutes , ipsilateral hind paw mechanosensitivity was assessed using a modification of the Dixon up—down method. If there was a positive response ie, withdrawal, shaking, or licking of the hind paw , the next lower strength hair was applied; if there was a lack of response, the next higher strength hair was applied up to a cut-off of 15 g bending force.
Hind limb weight bearing was tracked and recorded over a 3-minute period. Weight borne on the ipsilateral hind paw was calculated as a percentage of the total weight borne on the hind limbs. Animals underwent baseline von Frey hair mechanosensitivity and DWB testing. Separate cohorts were treated on day 14 post-MIA with an i. Behavioural pain measurements for these experiments were conducted at 30, 60, , , and minutes after drug administration.
A longitudinal incision was made along the ventral skin of the neck to expose the trachea which was cannulated with PE tubing to permit unrestricted breathing. Both hind limbs were immobilised and the capsule of the ipsilateral knee was exposed by surgically removing a small ellipse of the overlying skin and superficial fascia. Intravital microscopy was used to assess leukocyte-endothelial interactions within the microcirculation of the knee joint, as described previously.
In vivo leukocyte staining was achieved by intravenous administration of 0. Two measures of leukocyte-endothelial interactions were used to assess articular inflammation: Rolling leukocytes were defined as positively stained blood cells travelling slower than the surrounding blood flow, and adherent leukocytes were defined as positively stained cells that remained stationary for a minimum of 30 seconds.
At each time point, 1-minute recordings of the exposed knee joint were taken at a working distance of 10 cm with a frame capture rate of 25 images per second. At the end of the experiment, rats were euthanised and a dead scan of the knee was taken.
Images were analysed offline where mean blood perfusion perfusion units in a defined region of interest approximating the knee joint was calculated. Inflammation measures were conducted on day 1 post-MIA induction, which corresponds to the peak of inflammation in this OA model. Subsequent recordings were taken at 5, 15, 30, 60, , and minutes after drug administration. A segment of the saphenous nerve was isolated proximal to the ipsilateral knee joint and placed in 2.
The nerve samples were then removed from the fixative and rinsed 3 times with 0. Epon—araldite resin was used to mount the samples. The samples were placed in a 3: Finally, using an LKB Huxley ultramicrotome with a diamond knife, the samples were sectioned into nm thick slices. The microscope was set at a voltage of One nerve cross-section image was visually partitioned into 9 quadrants and 3 images were captured from quadrants 1, 5, and 9. All fibres were assessed using the G-ratio plugin in ImageJ processing software.
The G-ratio was calculated using the equation where, a is the internal axonal area and A is the total axonal area of the fibre. The higher the G-ratio the higher the degree of demyelination. Cannabidiol 2-[ 1 R ,6 R methyl 1-methylethenyl cyclohexenyl]pentyl-1,3-benzenediol was obtained from Tocris Bioscience Bio-Techne, Abingdon, United Kingdom.
AM CB 1 receptor antagonist; 1- 2,4-dichlorophenyl 4-iodophenyl methyl-Nmorpholinyl-1H-pyrazolecarboxamide and AM CB 2 receptor antagonist; 6-iodomethyl 2-morpholinylethyl indolyl]- 4-methoxyphenyl methanone were obtained from Cayman Chemicals Ann Arbor, MI.
Data were tested for Gaussian distribution by the Kolmogorov—Smirnov test. A P value less than 0. A total of 17 afferent fibres were recorded in this study.
On days 14 to 19 post-MIA induction, close i. Example of a single-unit recording whereby CBD attenuated firing evoked by noxious rotation A.
The dose-dependent effect of CBD treatment on afferent firing rate was averaged over the 15 minutes after administration C. Effect of contralaterally administered CBD on ipsilateral pain behaviour. Contribution of cannabinoid and noncannabinoid receptors to the analgesic effects of CBD. One day after i. Contribution of cannabinoid and noncannabinoid receptors to the anti-inflammatory effects of CBD.
Medical marijuana is becoming one of the most popular alternative treatments for chronic pain - this can range from pain caused by conditions such as migraines or arthritis to pain caused by injury. With over million Americans suffering from chronic pain, a safe and effective treatment is needed, and this does not exist with the presently available pharmaceutical options. The two main treatments currently available for relieving pain include nonsteroidal anti-inflammatory drugs NSAIDs and opioid prescription medications.
These pain relievers are not nearly as safe as cannabis. Opioid drugs are one of the most addictive drugs available today, and their use can be fatal if abused: While NSAIDs are generally effective at reducing pain caused by inflammation, prolonged use is accompanied by many dangerous side effects. These include increased risk of heart attacks and strokes. Medical marijuana is becoming a popular alternative to over-the-counter and prescription painkillers, and for good reason.
As a remedy for pain, pot comes with fewer side effects and no risk of tolerance or overdose. Cannabis sativa and its constituents have proven to be both safe and effective when it comes to pain management. With the legality of marijuana spreading across the United States and other countries, many people are now being given the opportunity to switch from dangerous, addictive medications to a natural, safer alternative.
Whether you are suffering from chronic nerve or body pain, or you are experiencing short-term pain from muscle strain, headaches, toothaches, or simply sore muscles, cannabis offers a safer and possibly more effective option than what is typically used for pain today. Throughout this time, the cannabis plant has been exalted as miraculous and cursed as a danger to the fabric of society.
Yet, throughout this varied past, one thing has remained the same: Cannabis has been used as a plant medicine for the treatment of an impressively wide array of diseases. The earliest evidence of its medicinal use dates back to BC when Chinese Emperor Shen Nung documented the analgesic pain-relieving properties.
Shen Nung is considered by many to be the father of Chinese medicine, which has helped to heal people through the use of natural remedies for thousands of years. We have now entered a time where the benefits of this plant are beginning to come back to the forefront of the discussion.
Indeed, countless individuals across the world have access to legal marijuana for chronic pain conditions. Should patients turn to singular compounds found in the plant, or turn to the plant itself? If using the whole plant, what marijuana strains are the best for providing relief from pain? When you compare Western medicine to traditional medicine the world over, one of the most striking differences is the need in the West to pinpoint one specific molecule that is responsible for treating a disease or symptom.
This viewpoint stands contrary to the idea of holistic medicine, where you take something in its entirety for medicinal purposes. The Cannabis sativa plant is one of the greatest present-day examples of this tug-of-war between Western medicine and traditional medicine.
It has been found to have a variety of health-related benefits for the user. CBD is the second most well-known cannabinoid found in cannabis, and like most of the other phytocannabinoids, it is non-psychotropic. These are the two most abundant and well-studied cannabinoids in marijuana, and both have been found in numerous published studies to have pain-relieving properties in humans. While they may be the most abundant, THC and CBD are certainly not the only compounds found in cannabis that are known to exert positive effects on human health.
In every cannabis plant, there is a unique mixture of hundreds of plant compounds, comprised of phytocannabinoids, terpenes, and flavonoids. Research suggests that these compounds too have an influence on our neurochemistry, and together they may work synergistically, producing better improvements in pain relief than anyone would produce on its own. This research supports the idea that it is best to use the whole cannabis plant, with CBD, THC, and the natural medley of additional compounds.
This harmony between the various plant chemicals found in marijuana is colloquially referred to as the entourage effect. The most well-studied compounds found in the marijuana plant that support the idea of the entourage effect are THC and CBD, which have been found to work differently together than when separate. Using these two compounds in concert has been shown to help mitigate side effects and enhance efficacy, with CBD plus THC showing more benefit for some conditions than THC alone.
It has also been found to extend the half-life of THC, which may help to extend the pain-relieving benefits. This has allowed the use of higher doses of THC in clinical trials for the treatment of pain caused by multiple sclerosis, peripheral neuropathic pain, intractable cancer pain, and rheumatoid arthritis. When used in concert, a greater efficacy in treating these types of pain have been observed. Every strain of bud that you can purchase at a dispensary will be labeled with its THC and CBD content, which can be helpful when choosing which strain to choose for pain relief.
CBD has been found to exhibit enhancements in treating pain both when used on its own and when used in combination with THC. When used alone, CBD is largely best for inflammatory pain, such as that caused by arthritis or injuries. In one animal study on arthritis pain, it was found that the topical application of CBD led to a reduction in inflammation and pain. Another animal study found that CBD helps to reduce neuropathic pain through the suppression of chronic inflammation.
CBD does not directly bind to the receptors found in the endocannabinoid system but rather works to modulate the effects of the endocannabinoids the cannabinoids found naturally in our bodies as well as working as a CB1 receptor antagonist.
The main mechanism by which CBD is thought to help mediate pain is by reducing inflammation , largely by blocking inflammatory mediators.
For instance, lip balms with THC allow you to stealthily get high by just licking your lips. This can result in a reapplication cycle even more enticing than that cherry-flavoured balm you had as a teen. There are personal lubricants for women infused with CBD or THC that are said to relax the vagina, increase natural lubrication and heighten sexual pleasure.
Do these creams really work? Are there THC creams? Does cannabis affect your memory? If I trade in my booze for pot, will I lose weight?
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CBD oil products are legal in all 50 states, so long as the THC When treating arthritis symptoms with CBD, most people will use either a standard oil tincture or a topical pain cream, but HempBombs is big into CBD edibles. CBD Oil for Arthritis Pain: Does It Relieve Symptoms? While marijuana contains some CBD, it is grown for its THC content. The topical CBD arthritis cream occasionally causes an allergic reaction, so test it on a small area. Relieve Arthritis Pain Naturally With CBD. October 3, It's designed to bring topical pain relief in under 30 minutes. It may help with.