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    Really all kinds of very good facts. Retrieved 30 June Journal of Psychoactive Drugs 13 1: J Psychoactive Drugs Review 43 2: Journal of Cannabis Therapeutics 2 2: Journal of Cannabis Therapeutics 1: Retrieved 2 December Medicine?: The Science Beyond the Controversy. National Cancer [88] Dr Farid F.

    What it is and Institute at the National Institutes of Health. Retrieved 24 August Re- ijuana - ProCon. Journal of Pharmacology Review 5: Retrieved 19 September The Jour- [] Bilkei-Gorzo A Se- ries B, Biological sciences Review Cochrane in retinal and eye research Review 27 5: Database Syst Rev Review 2: Dialogues Clin Neurosci 9 4: PMC noids and endocannabinoids in metabolic disorders with Lancet Neurol Review 4 3: A promising drug for neurodegenerative dis- Cochrane Database Syst Rev Review 6: Journal of psy- view Retrieved 19 Opinion on Investigational Drugs Review 12 1: Dig Dis Re- view 32 4: Increased restrictions and labeling of cannabis as a doi: Oakland Cannabis Buyers' Cooperative and Gonzales v.

    Raich that the federal government has a right 1. Thus, England's only colony in America. Retrieved 18 De- began to grow hemp in order to meet this obligation and, cember Medicinal preparations of cannabis Retrieved 23 September National Cancer Institute of licensed pharmacies and without a doctor's prescription. In , the section which enu- merated the substances was repealed with an amendatory act, though cannabis was still required to be labeled.

    Among those that required a prescription for that one could be found in every major city on the east coast. The Poison Act was passed in and 1.

    Previously, many drugs had been sold as patent vision placed cannabis under the same restriction as other medicines with secret ingredients or misleading labels. Under this act, the frame- tween the small farms and the large farms that used cheaper work for prescription and non-prescription drugs and foods Mexican labor.

    Shortly afterwards, the Great Depression are set, along with standards as well as the enforcing agency, came which increased tensions as jobs and resources be- the FDA. Because of that, the passage of the ject to seizure and destruction at the expense of the manu-initial laws is often described as a product of racism, yet facturer.

    The committee took into consideration the interstate accord abreast of international accord, fact that the federal government had already passed The to the honor of the legislative bodies of our Harrison Act in and The Federal Import and Export States and for the promotion of the welfare of Act in Many people assumed that the Harrison Act our people and the peoples of other lands.

    The act was recommended to the states for that pur- Anslinger claimed cannabis caused people to commit vio- pose. By the middle of the s all mem- and Anslinger often commented to the press regarding his ber states had some regulation of cannabis.

    Anslinger as part of the government's broader push to outlaw all recre- Main articles: Marijuana Tax Act of and Hemp ational drugs. Anslinger, ran a campaign against marijuana. If an alternative raw medicines, that power being reserved by individual states in material for paper had emerged, it would have lowered the , a tax was the only viable way to legislate marijuana.

    He considered nylon's success to depend on its replacement of the traditional resource, hemp. Silk was much more expensive than hemp and imported largely from Japan. There was more money in substitute for silk. DuPont focused early on thin stockings for women. As a commercial product was nylon a revolution in textiles. Due to the nylon properties become demand for nylon a number After the Philippines fell to Japanese forces in , the of years to come much bigger than that DuPont could pro- Department of Agriculture and the U.

    Army urged farm- duce. Merrill and Lyster H. Dewey cre- tween and Merrill ness, and overt sexuality. Numerous ma- FBN noticed an increase of reports of people smoking chines had been devised for breaking and scutching hemp marijuana, which further increased in The stem in the middle.

    The law reduced the penalty for personal possession of an ounce In its Leary v. Possession of more than since it violated the Fifth Amendment privilege against an ounce was made a misdemeanor, making the maximum self-incrimination. Prior to the law, the state had been spend- pealed the Marijuana Tax Act. CANNABIS Mandatory sentencing and three-strikes , In Gonzales the respondents criminal defendants argued because the cannabis in question had been grown, trans- During the Reagan Administration the Sentencing Reform ported, and consumed entirely within the state of Califor- Act provisions of the Comprehensive Crime Control Act nia, in compliance with California medical cannabis laws, of created the Sentencing Commission, which es- the defendants' activity did not implicate interstate com- tablished mandatory sentencing guidelines.

    Therefore, the defendants argued, their activity Drug Abuse Act of reinstated mandatory prison sen- could not be regulated, and eventually prosecuted, by the tences, including large scale cannabis distribution. Later an amendment created a three-strikes law, which cre- The U. Oakland Cannabis Buyers' Cooperative plies. Oakland Cannabis Buyers' violating federal law. However, the Obama administration has in- with a safe and reliable source of medical cannabis, infor- dicated that this practice may potentially be curtailed.

    Decriminalization of non-medical cannabis created as a result of Controlled Substances Act of Raich judge ruled Randall needed cannabis for medical purposes and required the Food and Drug Administration set up Main article: Raich a program to grow cannabis on a farm at the University of Mississippi and to distribute cannabis cigarettes a Gonzales v.

    In George H. Bush discontin- which the U. Thirteen people were medical cannabis programs are lawfully cultivating, pos- already enrolled and were allowed to continue receiv- sessing, or distributing medical cannabis, such persons or ing cannabis cigarettes; today the government still ships businesses are violating federal marijuana laws.

    There- cannabis cigarettes to four people. Irvin Rosenfeld, who fore, under federal law violators are prosecuted because the became eligible to receive cannabis from the program in Commerce Clause of the United States Constitution grants to treat rare bone tumors, urged the George W.

    Decriminalization of non-medical March issued a white paper recommending a halt to cannabis in the United States and Legality of cannabis by using marijuana as a medicine in US states where it has been U. The Commission found that the constitution- ality of cannabis prohibition was suspect and that the exec- drug policy of the United States to decriminalize cannabis. Stricter punishments exist for sale, cultivation, and proximity to schools.

    The introductory article concludes with the state- marijuana, instead making it a civil infraction punishable ment: Criminal penalties for cultivation and dis- take action on marijuana as it has been on other big issues.

    The citizens use of cannabis. Hickenlooper explained to the media: Sup- this industry will create jobs. Similar to Portland, state law where 16, , the Denver City Council adopted an ordinance for only medical marijuana is legal will likely be enforced, as retail marijuana establishments.

    Initiative 71 legalized the recreational usage of marijuana, with laws similar to those State-level legalization of Colorado and Washington. Unlike Ini- tiative , Amendment 64 allows personal cultivation of Territorial-level legalization up to 6 plants. Both provide for commercial cultivation and sales, subject to regulation and taxes. In December , the resolved. US Virgin Islands passed a bill that decriminalized posses- The city of Portland, Maine legalized the possession of up sion of cannabis up to an ounce.

    As with The act: State and Territories, the Federal government will not inter- vene as long as the reservations regulate strict control over Would reschedule marijuana from a Sched- marijuana. Some domestic nations such as the Yakama Na- ule I to Schedule II drug to recognize it has ac- tion and the Oglala Sioux Tribal Council rejected the ap- cepted medical use, and would amend federal law proval to allow marijuana on their reservation. The leg- islation would not legalize medical marijuana in all 50 states, rather it would respect the states 1.

    It was read twice and referred to the Com- The act has not yet been approved by the Congress. The intentions of the bill are to limit the application of Federal laws to the distribution and Respect State Marijuana Laws Act consumption of marijuana, and for other purposes. Drug court to drug policy reformation.

    The conventional criminal court with the possibility of serving bill was approved by the House in September Should the of- [10] Jones, Nick A Celebration of Cannabis Cul- fender fail to comply with one or more of the requirements ture. Septem- ber 14, Retrieved March 9, Puts a Ban on Hashish.

    Hemp — American History Revisited. Retrieved September 4, Drug Use and Abuse 4th ed. Drug Problems 26 2. Retrieved February 13, Bureau of Chemistry Plant Which Crazes Its Addicts. Whitebread and Richard J. A History of American Marihuana Prohibition.

    University of Virginia Law School. American and Canadian Plains, — The Life of William Randolph Hearst: Anslinger and the Federal Bureau of Narcotics, — University of Delaware Press. The Borderlands of the Ameri- University of Nebraska Press. Re- trieved May 26, Retrieved May 15, Re- [54] Rowe, Thomas C. Federal narcotics laws and the trieved March 25, Encyclopedia of Law Enforcement: Retrieved war on drugs.

    ISBN March 9, Commissioner of Narcotics and Will Oursler: The Murderers, the story of the narcotic [59] American Chemical Society: Dewey and Jason L. Retrieved March 25, Retrieved [62] Hayo M. Randall Fortenbery and Michael Bennett: Is Industrial [80] Volz, Matt July 11, The Seattle Times Frank A. Retrieved April 20, Retrieved March [68] Pub.

    Governor's Drug Policy mission Illinois to the Illinois General Assembly. Retrieved March 20, Illinois Legislative Investigating Commission. Retrieved July 7, Archived from the original on September 28, Retrieved April 30, Retrieved Jan- uary 2, The New York Times. Retrieved July 28, trieved March 9, Retrieved May 26, Brief History of Social Problems: United States Department of State. Retrieved cal thinking approach, Retrieved June 8, Retrieved May 26, [95] "http: Medical marijuana ruling puts spotlight on pend- ment of Justice, October 19, , http: San Francisco Bay Guardian.

    Retrieved April 24, Cultural and Historical Perspectives. ISBN [] http: New York Daily Retrieved May 29, The Denver cember 24, Post. Retrieved September 20, Re- [] Nick Allen December 31, Retrieved September 19, Retrieved February 27, Retrieved November 16, Retrieved February 26, American history re- visited: It implies an overwhelming in- ufacture, importation, possession, use and distribution of dictment of the behavior which we believe is not certain substances is regulated.

    It was passed by the 91st appropriate. The actual and potential harm of use United States Congress as Title II of the Comprehensive of the drug is not great enough to justify intrusion Drug Abuse Prevention and Control Act of and signed by the criminal law into private behavior, a step into law by President Richard Nixon.

    Single Convention on Narcotic Drugs. Congress has sometimes scheduled respects to liberalize, American drug policy. It elim- , which placed gamma hydroxybutyrate in Schedule I. States, and international treaties. The bill, as introduced by Senator Everett Dirksen, ran to 91 pages. While it was being drafted, the Uniform Controlled 1. Mitchell, was preparing a com- Substances. This re- ber 11, Once the stances EPCS Under certain circumstances, the The Controlled Substances Act consists of 2 subchapters.

    In ad- ates lawful and unlawful manufacturing, distribution, and dition, 21 U. In any case, once these proceedings are complete, the temporary order is automatically vacated. Unlike ordinary scheduling pro- 1. The ings to add, delete, or change the schedule of a drug or other cornerstone of this system is the registration of all those substance may be initiated by the DEA, the Department of authorized by the DEA to handle controlled substances.

    When a petition is received by the DEA, the agency begins its own investigation of the drug. The prohibitions of the the equality of treaties and Congressional acts.

    Covert the Supreme Court of the United States addressed Constitution were designed to apply to all branches of the National Gov- both these issues directly and clearly holding: This Court has reg- Constitution. For example, in Geofroy v. It would not be con- which intimates that treaties and laws tended that it extends so far as to au- enacted pursuant to them do not have thorize what the Constitution forbids, to comply with the provisions of the or a change in the character of the Constitution.

    It would treaties which concluded the Revo- be completely anomalous to say that a lutionary War, would remain in ef- treaty need not comply with the Con- fect. It would be manifestly con- stitution when such an agreement can trary to the objectives of those who be overridden by a statute that must created the Constitution, as well as conform to that instrument.

    Congress and the President of the United a treaty obligation under the Convention States have the absolute sovereign right to withdraw from on Psychotropic Substances. However, the Secretary has obligations violate the United States Constitution. If the Secretary agrees with the Commis- sion's scheduling decision, he can recommend that the At- torney General initiate proceedings to reschedule the drug 1. The temporary scheduling expires as scheme.

    The term does not include ing; however, control was required by the Convention on distilled spirits, wine, malt beverages, or tobacco, Psychotropic Substances. It has been shown to be asso- ciated with an increase in seizures if taken alone. MDMA, it can produce neuroadaptations that can cause an increase in the potential for abuse of this 1. The drug or other substance has a high drug. The drug or other substance has no cur- the shrub Catha edulis khat. There is a lack of accepted safety for use of psychedelic drug that is widespread throughout the the drug or other substance under medical plant kingdom and endogenous to the human body.

    The medical community orig- tion of a practitioner, except that in emergency situations, inally agreed upon placing it as a Schedule III sub- as prescribed by the Secretary by regulation after consulta- stance, but the government denied this suggestion, de- tion with the Attorney General, such drug may be dispensed spite two court rulings by the DEA's administrative upon oral prescription in accordance with section b law judge that placing MDMA in Schedule I was ille- of that Act 21 USC b.

    With exceptions, an orig- gal. To provide relief, in , 21 C. The drug or other substances have a Dexmethylphenidate Focalin: The drug or other substance has a currently accepted obesity medical use in treatment in the United States. Substances Act than for Schedule II though no schedule has Prior to October , formulations containing hy- provisions to address circumstances where the closed sys- drocodone and over-the-counter NSAIDs such as Ac- tem is unavailable, nonfunctioning or otherwise inadequate.

    Drugs in this schedule include: The drug or other substance has a potential for abuse Xyrem is in Schedule III but with a restricted distribu- less than the drugs or other substances in schedules I tion system. The drug or other substance has a currently accepted medical use in treatment in the 1. Abuse of the drug or other substance may Main article: Control measures are similar to Schedule III.

    The drug or other substance has a low within a six-month period. A prescription for controlled potential for abuse relative to the drugs or substances in Schedules III, IV, and V issued by a practi- other substances in schedule IV tioner, may be communicated either orally, in writing, or 2.

    Abuse of the drug or other substance may Additionally, the law restricts an individual to the retail lead to limited physical dependence or psy- purchase of no more than three packages or 3. A violation of this statute con- stitutes a misdemeanor. Retailers now commonly require No controlled substance in schedule V which is a drug PSE-containing products to be sold behind the pharmacy may be distributed or dispensed other than for a medical or service counter.

    Difenoxin with atropine Motofen has drugs. Without atropine, these drugs are in Schedule II. That bill was then super- seded by the Combat Methamphetamine Epidemic Act of , which was passed as an amendment to the Patriot 1. Raich [9] The Act: Oakland Cannabis Buyers' Cooperative [15]. Cato Handbook for Congress: It is an eclec- Archive copy at the Wayback Machine tic concept having only one uniform connotation: A Modern History vey on Drug Abuse.

    Their Derivatives [27] 21 U. Federal Register Drug ica: Clinical Toxicology 46 9: Clinical Toxicology 35 6: Drug harms in the UK: A multicriteria decision doi: The Lancet, , Retrieved 30 October Retrieved 3 September The most notable cannabinoid is the phy- doi: The botany and CBD is another major constituent of the plant. CB1 re- ceptors are absent in the medulla oblongata, the part of the brain stem responsible for respiratory and cardiovascular functions.

    Cannabinoid receptor type 2 Main article: While found only in the peripheral nervous system, a report does indicate that CB2 is ex- pressed by a subpopulation of microglia in the human cerebellum. It is only mildly psychoactive.

    Cannabigerol Tetrahydrocannabinol Main article: CBG has been shown to promote apoptosis in cancer cells and inhibit tumor growth in mice. Recent evidence shows that the compound counteracts cognitive impairment associated with the use of cannabis. Cannabichromene activity on human breast carcinoma by inhibiting cancer cell growth. CBD has been shown to play a role in preventing the short-term memory loss as- Biosynthesis Cannabinoid production starts when an sociated with THC.

    For the propyl homo- chosis. Trials indicated it was safe and well tolerated. Cannabis plants can exhibit wide variation in the quantity and type of cannabinoids they produce. Selective breeding has been used to position of the double bond in the alicyclic carbon ring. Under the dibenzopyran numbering system choactive chemicals like THC. Liquid chromatography LC techniques are also pounds. There have to the aromatic ring. In the most common of cannabis over time, but their accuracy is impeded by the homologue, the pentyl chain is replaced with a propyl 3- illegal status of the plant in many countries.

    Pharmacology Cannabinoids can be administered by smoking, vaporiz- ing, oral ingestion, transdermal patch, intravenous injec- Cannabinoids in other plants tion, sublingual absorption, or rectal suppository. Once in the body, most cannabinoids are metabolized in the liver, Phytocannabinoids are known to occur in several plant especially by cytochrome P mixed-function oxidases, species besides cannabis. Hydrocarbons and alcohols are often Most of the phytocannabinoids are nearly insoluble in wa- used as solvents.

    Butane may be used, which evap- organic solvents. Due to molecular similarity and ease of synthetic conver- All of these are members of a family of signalling sion, CBD was originally believed to be a natural precursor lipids called N-acylethanolamines, which also includes to THC. Arachidonoylethanolamine nal immobility, and mild antinociception in mice.

    It binds primarily to the CB1 receptor, and only weakly to the CB2 receptor. Anandamide is derived from N-Arachidonoyl dopamine arachidonic acid. Activation of cannabinoid receptors temporar- for the vanilloid receptor subtype 1 TRPV1 , a member of ily reduces the amount of conventional neurotransmitter re- the vanilloid receptor family. Virodhamine cell depends on the nature of the conventional transmit- ter being controlled. Al- is an increase in the excitability of the endocannabinoid- though it is a full agonist at CB2 and a partial agonist at releasing cell.

    On the converse, when release of the ex- CB1 , it behaves as a CB1 antagonist in vivo. In rats, virod- citatory neurotransmitter glutamate is reduced, the net ef- hamine was found to be present at comparable or slightly fect is a decrease in the excitability of the endocannabinoid- lower concentrations than anandamide in the brain, but 2- releasing cell.

    Lysophosphatidylinositol LPI Recent evidence has They cannot travel unaided for long distances in the aqueous highlighted lysophosphatidylinositol as the endogenous lig- medium surrounding the cells from which they are released, and to novel endocannabinoid receptor GPR55, making it and therefore act locally on nearby target cells.

    Hence, al- a strong contender as the sixth endocannabinoid. Function Endocannabinoids serve as intercellular 'lipid messengers', 1. Although in this intercellular signaling role they are similar to the well-known monoamine neurotransmitters, Historically, laboratory synthesis of cannabinoids were of- such as acetylcholine and dopamine, endocannabinoids dif- ten based on the structure of herbal cannabinoids, and a fer in numerous ways from them. For instance, they are large number of analogs have been produced and tested, used in retrograde signaling between neurons.

    Further- especially in a group led by Roger Adams as early as more, endocannabinoids are lipophilic molecules that are and later in a group led by Raphael Mechoulam. Newer not very soluble in water. They are not stored in vesicles, compounds are no longer related to natural cannabinoids and exist as integral constituents of the membrane bilay- or are based on the structure of the endogenous cannabi- ers that make up cells.

    They are believed to be synthe- noids. The mechanisms and enzymes underlying the biosynthesis Synthetic cannabinoids are particularly useful in exper- of endocannabinoids remain elusive and continue to be an iments to determine the relationship between the struc- area of active research.

    Endocannabinoids, on the other Medications containing natural or synthetic cannabinoids or hand, are described as retrograde transmitters because they cannabinoid analogs: Pharmacological Reviews 58 3: CB1 receptor inverse agonist once used as an anti- doi: It [2] Lambert, Didier M.

    Journal of Medic- inal Chemistry 48 Other notable synthetic cannabinoids include: Journal of Natural Products 79 2: Retrieved 6 June A Cellular and Molecular Approach. Progress in Lipid Research 50 2: European Journal of Biochemistry 6: US Patent application number: Some physical and chemical fea- Bulletin on narcotics 32 2: Schizophrenia Research American Journal of Botany 91 6: British Journal of Pharmacol- ogy 7: Neurochemical Research 30 8: Behavioural Pharmacology 16 5—6: The Journal of Pharmacol- [28] http: Retrieved 6 October Journal of Medicinal Chemistry 43 Planta Medica 63 1: British Journal of Pharmacology 1: Journal of Chromatography A 2: Plant Physiology 4: The plant-derived yangonin is a novel CB1 recep- Pharmacological Research 66 2: Drug Metabolism Reviews 46 1: Pro- [39] Ashton CH February Br J Psychiatry 2: They are then slowly released back into other body Mayumi; Suhara, Yoshitomo; Takayama, Hiroaki; Waku, compartments, including the brain.

    They are then slowly Keizo; Sugiura, Takayuki Journal nation half-life of THC is about 7 days, and complete elim- of Neurochemistry 85 6: Annual Review of Neu- Yu. Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with [41] Grotenhermen, Franjo Life Sciences 65 6—7: Life Sciences 78 macology and Experimental Therapeutics 3: Journal of Medicinal Chem- istry 36 Update on Chemistry, new cannabinoid acids from Cannabis sativa L. Med can Journal of Drug and Alcohol Abuse 0 0: Drug and Chemical Schatz, Anthony R.

    Oc- cal Pharmacology 50 1: Journal of Neuroscience 28 Science Rehnelt, J. In , the binding of several cannabinoids Journal of Natural Products 44 1: Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. Subtype se- lective cannabinoids have been developed which theoreti- cally may have advantages for treatment of certain diseases 1.

    Cannabinoid receptor type 1 Cannabinoid receptor type 1 CB1 receptors are thought to be one of the most widely expressed G protein-coupled receptors in the brain. This is due to endocannabinoid- mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission.

    Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a re- CB1 and CB2 structures. Cannabinoid receptors, located throughout the body, are They are also found in other parts of the body. For instance, part of the Endocannabinoid system which is involved in a in the liver, activation of the CB1 receptor is known to in- variety of physiological processes including appetite, pain- crease de novo lipogenesis.

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