Prostate cancer is the second most prevalent form of cancer amongst American men, behind skin cancer. According to the American Cancer. Cannabis oil has been on the minds of men with prostate cancer. Are There Any Facts Showing Cannabis Works? such as CBD (cannabidiol) can kill or slow the growth of certain cancer cells growing in laboratory dishes. Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 Despite the fact that a higher percentage of men have localized disease at . [ 52] Cannabidiol (CBD), another major constituent of the Cannabis sativa plant.
for the [Exploring Facts] CBD Cancer Prostate
Numerous treatment options have been established to treat bone metastatic prostate cancer; some focus on treating the underlying pathophysiology, while others focus on pain management and palliative care.
More local modalities also considered in today's medical world are focal external beam radiation therapy, an excellent treatment choice for men with castrate-resistant prostate cancer and bone pain that is limited to one or a few sites, bone-targeted radioisotopes strontium 89Sr and samarium Sm for multiple blastic bone lesions, and radiofrequency ablation. Cannabis is a bushy plant with palmate leaves and clusters of small green flowers, and it grows wild in regions of tropical weather and can attain up to 3 m height.
The genus Cannabis is complemented by sativa which translates to useful. Cannabis has indeed been used throughout history for a variety of purposes, including the production of fiber for paper and textile manufacture.
However, its current popularity lies in its use as a recreational drug with psychoactive properties. The plant contains many chemical compounds that have different pharmacological properties, varying in quantity and quality depending on the strain, culture, and storage conditions. In , Mechoulam and colleagues[ 14 ] found that deltatetrahydrocannabinol THC was the major psychoactive ingredient of cannabis.
However, the endocannabinoid signaling system has only been the focus of medical research and considered a potential therapeutic target in recent times.
Two different cannabinoid receptors have been described from mammalian tissues: The frequently held view of cannabis and its related products as drugs of abuse have slowed progress in the development of studies designed to take advantage of the properties of cannabinoid derivatives for therapeutic purposes.
The antagonizing effect of cannabinoids in the male reproductive system and physiology can be dated to where experimental models in male rats showed depression of spermatogenesis[ 21 ] and decrease in circulating testosterone levels.
In recent years, cannabinoids and their derivatives have drawn renewed attention due to the discovery of diverse pharmacologic activities such as cell growth inhibition, anti-inflammatory effects, and tumor regression. When the same cells were pretreated with cannabinoid receptor antagonists SR CB1 antagonist or SR CB2 antagonist , the coadministration of WIN, had no effect on cell viability, exhibiting a significant protective effect.
Androgens are involved in the maintenance and progression of prostate cancer, where the androgen receptor is assumed to be the essential mediator for androgen action. Curiously enough it was determined that high cannabinoid CB1 receptor immunoreactivity is associated with greater disease severity and poorer outcome in prostate cancer patients.
Patients with high CB1 receptor immunoreactivity showed a significantly worse survival rate than those with low CB1 receptor immunoreactivity hazard ratio 2. A possible explanation for these results that is in synch with the cell line data is that the expression of CB1 receptors is regulated by the local endocannabinoid release.
The author's conclusion in this scenario was that a low endocannabinoid tone would allow for an increased rate of proliferation, resulting in a compensatory increase in surface expression of CB1 receptors.
Cannabinoid CB1 receptors are found mainly in the central nervous system and, in less abundance, in certain peripheral tissues. Activation of presynaptic CB1 receptors in different brain regions or on primary afferents inhibits the release of neurotransmitters by decreasing calcium conductance and by increasing the conductance of potassium.
DeltaTHC is the substance with the greatest psychoactive potency of the natural cannabinoids and exhibits the greatest analgesic activity.
Studies with CBD derivatives developed to inhibit peripheral pain responses and inflammation after binding to cannabinoid receptors have been described. Interestingly, some of these CBD derivatives did not have central nervous system effects, but maintained their antinociceptive and anti-inflammatory properties. This means that centrally inactive synthetic CBD analogues may be candidates for the development of analgesic and anti-inflammatory drugs for peripheral conditions[ 53 ] without major central nervous system alterations of the sensorium.
In animal models of cancer bone pain, synthetic cannabinoids reduced hyperalgesia by a CB1 receptor-mediated effect and possibly at the peripheral CB2 receptor. In some models, cannabinoids were superiorly effective in cancer pain when compared with other pain types. Clinical trials have shown that nonselective cannabinoid receptor agonists are relatively safe and therapeutically efficacious, however, inducing also psychotropic side effects.
Cannabinoid efficacy has also been studied clinically in cancer pain. Initial studies quantified the modest efficacy of oral 20 mg D9-THC equivalent to mg codeine with some sedation, dizziness, and confusion. Nabilone did not significantly increase adverse effects compared with the control group, and this fact could be attributed to the concurrent decrease in opioid dose.
Uncontrolled pain can cause unnecessary suffering, decreased ability to cope with illness, interference with daily activities and extended hospital admissions, and decreasing overall quality of life. Step 1 of the ladder is for patients with mild to moderate cancer-related pain. These should first be treated with acetaminophen or a nonsteroidal antiinflammatory agent NSAID , possibly combined with an adjuvant drug that provides additional analgesia i.
Step 2 describes patients with moderate or severe pain, including those who do not achieve adequate relief after a trial of an NSAID alone; these should be treated with an opioid. The analgesic ladder promoted the doctrine of using an opioid of inferior analgesic properties i. On both steps 2 and 3, combination therapy that includes an NSAID or other drugs to enhance analgesia or treat side effects is advocated.
The combination of two antinociceptive drugs acting through different specific receptor systems provides major benefits. When synergistic substances are given in combination, the required dose of each agent can be reduced to less than would be explained by mere addition of individual effects. The clinical benefit of this property is fundamental in analgesic treatments because effective pain relief can be achieved with minor, fewer, or no side effects.
Chronic pain is a difficult subject to approach both for the patient and the treating physician and, not uncommonly, leads to chronic opiate consumption and dependence.
Cannabis has been documented to be one of such measures. As with any therapeutic modality, adverse effects must be taken into account. A number of patients will suffer from these, although most of them will be present within the first days of treatment and attenuate as they adjust to the drug. Chronic cannabis use does not produce serious cognitive disorders, as occurs with other substances such as alcohol, but it can aggravate preexisting mental disease.
Therefore, treatment with cannabinoid receptor agonist with central actions may be contraindicated, in individuals predisposed to or with current psychiatric disorders.
No human deaths associated to cannabis use have been reported. Prostate cancer is a grave public health problem worldwide. For these reasons, it is fundamental to invest time and intellectual resources into finding new and novel targets for the treatment of prostate cancer.
It seems that the studies of Sarfaraz and colleagues lead to the direction that cannabinoids should be considered as agents for the management of prostate cancer, pending support from in vivo experiments. This would not only make sense from an anti-androgenic point of view but also for men with bone metastatic prostate cancer, perhaps from a pain management or palliative point of view.
Among the patients suffering with chronic pain and receiving opioids, one in five abuse prescription controlled substances,[ 69 , 70 ] and it is not difficult to see that opioid dependence and abuse is becoming a public health problem. Different methods of managing pain should be addressed to avoid these scenarios. The presence of pain in men with advanced prostate cancer is an immediate indication for aggressive management with analgesics, while adequate treatments that address directly the cause of the pain are pursued.
These compounds harbor analgesic properties that aid bone cancer pain, reduce opioid consumption, side effects, and dependence, as well as exhibiting anti-androgenic effects on experimental prostate cancer cells.
Cannabis sativa and its main active component deltaTHC have long been used for numerous purposes throughout history including medicinal, textile, and recreational. Since its legal banning in the United States in , it has become an issue of taboo and controversy, frowned upon for its recreational uses and psychotropic effects. My doctor says testosterone can fuel prostate cancer. But the therapy has lots of side effects including the loss of sexual desire.
I really hope I can avoid this treatment if there is an alternative. I am not sure if my doctor will approve of the treatment. I would appreciate knowing how to approach my doctor, or what steps to take to obtain cannabis oil. I believe that this natural remedy is going to be a breakthrough in cancer research. As you are likely aware, the federal government recently changed the rules that regulate access to medical marijuana.
You now have to obtain permission from a physician before being able to order it from a licensed supplier. In the past, Health Canada controlled who could legally use cannabis. There have been a few notable exceptions to this generally negative reaction from the medical community. So you might think that he would be sympathetic to your point of view.
Juurlink said in a telephone interview. The study that you saw online involved experiments conducted on animals and tissue samples in a lab. The research is not yet at the stage where it has moved into human clinical trials. Although marijuana has been studied for years, there is a dearth of high-quality research exploring its potential medicinal uses.
What can be said is that cannabis may have a role in the control of certain symptoms. Some patients may find it helps relieve pain or improves appetite while they are undergoing chemotherapy. Control of symptoms is one thing, but stopping or slowing the advance of a disease is something else entirely.
After all, more than 20 U. That means ADT will have some effect on the vast majority of patients, though the degree of response varies from one individual to the next, says Dr.
Emmenegger, who specializes in treating men with metastatic prostate cancer. As your doctor correctly explained, prostate cancer is partly fuelled by male hormones, or androgens, which include testosterone. Take those hormones out of the equation and prostate cancer tends to shrink or grow more slowly for a while. Eventually, though, the cancer finds a way around the hormone shortage and resumes its growth.
ADT basically buys patients more time. For the record, women also produce some testosterone, but men make a lot more of it. This end result can be achieved by surgically removing the testicles or by taking certain medications that lower androgen production. Essentially, the patient is castrated — either physically or chemically — which results in a wide range of unpleasant side effects. In addition to the loss of libido and problems maintaining an erection, a man may also suffer from hot flashes, fatigue, depression, muscle loss, weight gain, thinning bones and even breast enlargement.
In some respects, men on ADT experience many of the same adverse effects faced by women during menopause. However, in most cases, it also has an almost immediate effect in slowing the advance of the cancer.
Emmenegger says there are ways to lessen some of the side effects. For example, certain medications may help to treat erectile dysfunction. Other drugs can minimize bone loss.
And if depression is an issue, it may be worthwhile seeing a psychologist or psychiatrist with expertise in treating cancer patients. Not so long ago, most men on ADT suffered in silence. The book — which can be purchased through online book dealers — includes contributions from 10 Canadians experts.
Wassersug knows first hand of what he speaks. He was diagnosed with prostate cancer in at the age of When the surgical removal of his prostate gland and radiation therapy failed to stop the cancer, Prof.
Wassersug decided to go on ADT. Since then, he has become an outspoken advocate for prostate cancer patients, urging men to be as informed as possible about their condition.
You may find that discussion extremely helpful in making an informed decision about the next stage of your cancer treatment. Yes, add me to your mailing list. Rather, what you are doing is promoting another treatment and the purchase of a book.
The title of your article is misleading and your hidden agenda has been exposed. But I think you are missing my point. The problem is that there is a lack of good quality research looking at the effects of marijuana on human cancer patients. You will find a web link to overview study embedded in the text.
But that information is based on research conducted on animals or in cell cultures in a lab. By contrast, there is ample evidence showing that hormone-deprivation therapy has an effect on prostate cancer. Agreeing with alex, as far as I know, there is no complete cure for cancer, kemo can sometimes make a patient worst or better, the cancer can have low numbers, bt always have the possiblity of coming back worst, if you know someone who is suffering from cancer, then you would understand that any remedy to make them feel better is a option, my dad suffers frm postate cancer, even thou he hates tht I smoke weed for personal reasons, I believe it might help in relieving stress, when a patient is strong mentally that is the best medicine.
All you are doing is driving people away from what could possibly be a legitimate medicine in combatting cancer, especially prostate cancer. Since cannabis is still a controlled substance and a Schedule I drug, the level of research into its efficacy for prostate cancer — or any other condition for that matter — is limited.
However, the small amount of research that has filtered through has been positive, and is indeed encouraging for those men currently suffering from prostate cancer. Lastly, we should point out a couple of important things. First, while CBD could help slow the progression of prostate cancer cells or even aid in their programmed self-destruction, you should not rely on it at this point in place of your doctor-recommended medications.
After all, there is a big difference between treating nausea, and treating cancer. Homemade oil is usually filled with toxins , and it is very unlikely that it will help combat your prostate cancer any more than a filtered, pure CBD oil would.
Will you please provide the link to this: The British Journal of Pharmacology published a study in I was just diagnosed with prostate cancer with a Gleason 6. Does anyone have this experience who can share? However, be careful, hormonal cancers like prostate and breast respond better to high CBD: THC, while it is the other way around for the others. Leave a Reply Cancel reply. Your email address will not be published. Remember me Lost your password?
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Can Cannabis Oil Cure Prostate Cancer?
The truth about the healing powers of cannabis is starting to see the light of Spain, who has been studying the molecular activity of cannabinoids for as well as cannabidiol dramatically reduced breast cancer cell growth. Come on Moyad Man, what is the truth here? side effects really fast like they are studying for a career in auctioneering. The future of research for cancer and the treatment of side effects will be the impact of CBD in many. MEDIKAL MARIJUANA: CANNABIDIOL (CBD) DAN #KANSER #PROSTAT ( KAJIAN). CBD for Prostate Cancer [Exploring the Facts] Medical Marijuana.