studies, there is little evidence of actual results in humans except in the .. Cannabinoids and cancer: potential for colorectal cancer therapy. Biochem Soc Trans. One of the companies pioneering the research and development of compounds that show good potential for cancer-fighting properties. Cannabis has been used medicinally for millennia, but has not been approved by the U.S. Food and Drug Administration to treat any medical.
on Potential a Cannabis Cancer Treatment Studies as
Data collected to date regarding anticancer effects of cannabinoids are almost completely limited to preclinical studies conducted on cell lines and animal models. The first experiment that was conducted on human subjects was a pilot clinical study on nine terminal patients with recurrent glioblastoma who were resistant to the standard therapy Patients received THC intratumorally.
This way of administration was safe and patients did not exhibit any overt psychoactive effects. In some patients the tumor growth rate decreased.
Changes observed upon THC administration in two patients can be connected with anticancer effect of THC according to previous preclinical studies decreased cell proliferation, occurrence of apoptosis Despite these interesting observations, it is not possible to draw significant conclusions from the study on a group of nine.
This shows a need for further clinical trials, which could help to assess the dosage and the potential interaction of cannabinoids with other substances.
These studies are currently ongoing or have ended recently, but the results have not been published to date. Cannabis plants produce a substantial amount of cannabinoids and other secondary metabolites. It has been demonstrated that extracts of Cannabis exhibit stronger effects on the subjects with spasticity than pure THC Some cannabinoids have been demonstrated to attenuate psychoactive effects of THC or smoked marijuana 13 , Pure cannabinoids are more convenient for study and to a subsequent standardization as a medical preparation, but still Cannabis extracts with specified amounts of cannabinoids seem to be valuable aim for further studies, also as potential anticancer agents.
An interesting idea is a combination of cannabinoids with conventional anticancer drugs, which can exhibit synergistic potential. The promising results from studies on animal models of glioblastoma treated with THC and temozolomide have led to, mentioned above, clinical trial of this chemotherapeutic agent and Sativex 94 , Similar observations from the study on pancreatic adenocarcinoma showed that gemcitabine administered with cannabinoids synergistically inhibited cancer cell growth To date, Cannabis or its preparations have found an application in a palliative medicine due to its analgesic and antiemetic effects, an attenuation of the side effects of chemotherapy or a capacity to treat spasticity in multiple sclerosis.
We are still initial stages of incorporating Cannabis products in the clinical care. There is still a lack of profound safety and efficacy clinical trials and it is very difficult or even impossible to assess the potential benefits and risk of using cannabinoids in many cases. Many aspects wait for an elucidation: The most common way of using recreational marijuana is smoking, which is unsuitable way of an administration from a medical point of view.
Another important issue is the lack of easy accessible biomarkers showing the responsiveness of patients to a cannabinoid treatment. Moreover, antitumor effects of cannabinoids have to overcome their known immunosuppressive effects which can be potentially protumorigenic. The interactions between cannabinoids and classical cytotoxic agents have to be precisely defined.
These observations lead us to the conclusion, that further profound studies are doubtlessly needed to verify the idea of introducing cannabinoids into the cancer treatment. National Center for Biotechnology Information , U. Journal List Cancer Med v. Published online Feb Author information Article notes Copyright and License information Disclaimer.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. This article has been corrected. This article has been cited by other articles in PMC. Abstract To date, cannabinoids have been allowed in the palliative medicine due to their analgesic and antiemetic effects, but increasing number of preclinical studies indicates their anticancer properties.
Introduction Nowadays, we observe an increasing public and scientific interest in the medical applications of Cannabis plants. Endocannabinoid system and cancer Despite numerous studies conducted during the last decade, there are still inconsistent data regarding the exact role of cannabinoid system in cancer development.
Open in a separate window. Cannabinoids and the immune system The mechanism of the immunomodulatory effects of cannabinoids is still not fully elucidated. Selectivity and stimulation of viability Viability of noncancerous cells seems to remain unchanged or sometimes even elevated by cannabinoids 34 , 35 , 36 , 39 , Inhibition of angiogenesis and metastasis Besides the above described proapoptotic effect in cancer cells, cannabinoids exhibit some other important and potentially valuable properties.
Anticancer effects of cannabinoids in clinical trials Data collected to date regarding anticancer effects of cannabinoids are almost completely limited to preclinical studies conducted on cell lines and animal models. Conclusions Cannabis plants produce a substantial amount of cannabinoids and other secondary metabolites. Conflict of Interest The authors declare that they have no conflict of interest.
Supporting information Table S1. Click here for additional data file. The use of medical marijuana in cancer. State Medical Marijuana Laws [Internet]. International union of basic and clinical pharmacology. Cannabinoid receptors and their ligands: Medical marijuana for cancer. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Molecular characterization of a peripheral receptor for cannabinoids. Cannabinoid pharmacology in cancer research: A new hope for cancer patients?
Towards the use of cannabinoids as antitumour agents. Springer, Berlin, Heidelberg; [cited Jan 4]. Handbook of Experimental Pharmacology. Endocannabinoid signaling as a synaptic circuit breaker in neurological disease. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Cannabinoids for Medical Use. Anticancer mechanisms of cannabinoids. Some of the children used cannabis alongside treatments like chemotherapy, while others turned to the drug after conventional treatments had failed.
Lake became interested in medical marijuana when her late ex-husband, Christian Evans , began researching cannabidiol CBD — a compound in marijuana that does not cause a high —for his own health issues, including chronic pain and ADHD. Evans died by suicide last year. The two met a young girl with a tumor disorder whose family was desperate to get her off chemotherapy, and they helped connect her with a doctor who specializes in medical marijuana.
Lake and her production partner, director Abby Epstein, were inspired to find other families in similar situations and tell their stories on screen.
They made Weed the People to explore the potential of medical marijuana, and the regulatory challenges families and researchers must overcome to use it.
The film paints a rosy, anecdotal picture of the effectiveness of cannabis oils; some of the children featured had their tumors shrink substantially or disappear entirely, even if they were using cannabis oils in place of chemotherapy and other conventional treatments.
But the concept is far from proven and could even be dangerous. Two of the most encountered side-effects of chemotherapy are intense vomiting and nausea.
Cannabis has been shown to combat both of these side effects, offering individuals who undergo chemotherapy respite from these adverse reactions. Cannabis, and more specifically, cannabinoids have been shown to decrease pain, increase appetite, and reduce the nausea commonly encountered in cancer patients who undergo chemotherapy. Additionally, cannabis can also serve to inhibit cancer progression and decrease chemotherapy-induced neuropathy.
As a tumor grows, it can metastasize and spread to various parts of the body. As these tumors begin to spread, the human body becomes unable to support such rapid growth, oftentimes resulting in death.
In a talk given at CannMed , Debra Kimless MD, detailed the promise of low-dose cannabis oil and its potential to improve the quality of life of those suffering from cancer. Additionally, a Harvard study found that in laboratory and animal studies THC cut the growth of tumors while diminishing its ability to spread to other parts of the body.
Cannabinoids are thought to combat cancer through a variety of means including inciting apoptosis, preventing the growth of the cancerous cells, and reducing or preventing the production of traveling cancerous cells.
'Weed the People’ Explores Medical Marijuana for Kids With Cancer
Keywords: Cancer, Cannabidiol, Cannabinoids, Cannabis, CBD, and clinical studies that Cannabis and cannabinoids have a therapeutic potential in Cannabinoids and the immune system: potential for the treatment of. We are increasingly being asked about cannabis and its potential effects on cancer, stages of research ultimately do not turn out to be good cancer treatments. Does cannabis have a potential to revolutionize cancer treatment? And although many studies have already revealed what prominent.